GDF15 Propeptide Promotes Bone Metastasis of Castration-Resistant Prostate Cancer by Augmenting the Bone Microenvironment

Medicine, Urology, Oncology, Life Sciences, Biochemistry,
Castration-Resistant Prostate Cancer   Bone Metastasis   GDF15   Biomarker   Bone Microenvironment  

Research Objective This study aims to identify specific proteins secreted by prostate cancer cells through comprehensive proteomic analysis and explore their role in bone metastasis, with the goal of discovering blood biomarkers that can improve the prognosis of patients with metastatic castration-resistant prostate cancer (mCRPC). Research Team an...

BRD4 Inhibitor Reduces Exhaustion and Blocks Terminal Differentiation in CAR-T Cells by Modulating BATF and EGR1

Medicine, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
CAR-T cell exhaustion   BRD4 inhibitor   single-cell RNA sequencing   transcriptional factors   acute myeloid leukemia  

Acute myeloid leukemia (AML) is the most common type of leukemia in adults. Although most AML patients achieve complete remission after standard chemotherapy, refractory and relapsed disease remain a significant challenge. Over the past decade, immunotherapy has been widely applied in cancer treatment, particularly chimeric antigen receptor T-cell ...

Exosomal PSM-E Inhibits Macrophage M2 Polarization to Suppress Prostate Cancer Metastasis Through the RACK1 Signaling Axis

Medicine, Urology, Oncology,
prostate cancer   exosomes   macrophage polarization   RACK1 signaling pathway   tumor microenvironment  

Exosomal PSM-E Inhibits Macrophage M2 Polarization to Suppress Prostate Cancer Metastasis via the RACK1 Signaling Axis Academic Background Prostate cancer (PCA) is a prevalent cancer among men and the second leading cause of cancer-related deaths. While early-stage prostate cancer can be treated with surgery or radiotherapy, approximately one-third...

Validation of a Prognostic Blood-Based Sphingolipid Panel for Men with Localized Prostate Cancer Followed on Active Surveillance

Medicine, Urology, Oncology,
sphingolipids   prostate cancer   active surveillance   biomarkers   risk stratification  

Study on a Prognostic Blood-Based Sphingolipid Panel for Men with Localized Prostate Cancer on Active Surveillance Academic Background Prostate cancer is one of the most common cancers among men globally, particularly for those with low- and intermediate-risk prostate cancer, where active surveillance (AS) has become the preferred management strate...

The Spatial Impact of a Western Diet in Enriching Galectin-1-Regulated Rho, ECM, and SASP Signaling in a Novel MASH-HCC Mouse Model

Medicine, Hepatobiliary System, Gastroenterology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Western Diet   Galectin-1   Rho Signaling   ECM Remodeling   SASP Signaling   MASH-HCC   Tumor Microenvironment  

The Spatial Impact of a Western Diet in Enriching Galectin-1-Regulated Rho, ECM, and SASP Signaling in a Novel MASH-HCC Mouse Model Academic Background Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, and metabolic dysfunction-associated steatohepatitis (MASH) is one of the primary triggers of HCC. With ...

Liquid Biopsy versus CT: Comparison of Tumor Burden Quantification in 1065 Patients with Metastases

Medicine, Medical Imaging, Oncology,
liquid biopsy   tumor burden   CT scan   metastatic cancer   quantification  

Comparison of Tumor Burden Quantification between Liquid Biopsy and CT Academic Background In the era of precision medicine, the validation of non-invasive biomarkers faces numerous challenges. Tumor burden, as a potential prognostic marker, has been demonstrated to hold significant value in various studies. Tumor burden refers to the total amount ...