Impact of Dietary Zinc on Stimulated Zinc Secretion MRI in the Healthy and Malignant Mouse Prostate Academic Background Zinc (Zn²⁺) is an essential trace element in biological systems, participating in various physiological processes, including enzyme catalysis, structural regulation of transcription factors, immune system modulation, and cell prol...

Academic Background and Problem Statement In cancer research, gene amplification is a common form of mutation, particularly in the activation of oncogenes. However, despite the widely recognized importance of gene amplification in cancer, precisely modeling these amplifications in primary cells and model organisms remains a challenge. Specifically,...

Academic Background and Problem Statement In recent years, immune checkpoint inhibitors (ICIs) have made significant progress in cancer treatment, particularly anti-PD-1 and anti-PD-L1 antibodies, which have become the standard of care for first-line treatment in various cancers. However, despite the notable clinical activity of these therapies in ...

Report on the Academic Paper Paper Source The paper, titled “Modulation of TCR Stimulation and Pifithrin-α Improves the Genomic Safety Profile of CRISPR-Engineered Human T Cells,” was authored by Laurenz T. Ursch, Jule S. Müschen, Julia Ritter, and others from institutions such as the Technical University of Munich and the University of Freiburg Me...

Academic Background The tumor microenvironment (TME) is a critical area in cancer research, where tumor cells interact with surrounding non-tumor cells to influence disease progression and therapeutic responses. Tumor-associated macrophages (TAMs) play a pivotal role in tumor growth, angiogenesis, and immune suppression. Recently, the role of metab...

Report on the Academic Paper: “Multi-modal Analysis Reveals Tumor and Immune Features Distinguishing EBV-positive and EBV-negative Post-transplant Lymphoproliferative Disorders” Summary The Epstein-Barr virus (EBV) is a widely disseminated gamma-1 herpesvirus that infects approximately 90%-95% of adults globally. While EBV infection is typically as...