Daratumumab in Pediatric Relapsed/Refractory Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma: The DELPHINUS Study

Medicine, Pediatrics, Hematology, Oncology, Life Sciences, Immunology,
Daratumumab   Acute Lymphoblastic Leukemia   Lymphoblastic Lymphoma   Pediatric   Relapsed/Refractory   DELPHINUS Study   Chemotherapy  

Daratumumab in Pediatric Relapsed/Refractory Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma: The DELPHINUS Study Academic Background Acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LL) are among the most common malignancies in children. Although the cure rate for newly diagnosed ALL and LL patients is relatively high, 10% to ...

Lactate Secreted by Glycolytic Conjunctival Melanoma Cells Attracts and Polarizes Macrophages to Drive Angiogenesis in Zebrafish Xenografts

Medicine, Ophthalmology, Oncology, Life Sciences, Immunology,
angiogenesis   conjunctival melanoma   macrophages   glycolysis   lactate   zebrafish model  

Academic Background Conjunctival Melanoma (COM) is a rare but potentially lethal ocular cancer, particularly when metastasis occurs, with limited treatment options. Although current treatments for primary conjunctival melanoma are relatively effective, once metastasis occurs, patient survival rates drop significantly, with most patients surviving l...

Somatic RIT1 Delins in Arteriovenous Malformations Hyperactivate RAS-MAPK Signaling Amenable to MEK Inhibition

Medicine, Oncology, Life Sciences, Immunology, Genetics,
arteriovenous malformation   RIT1 gene   RAS-MAPK signaling   MEK inhibitor   vascular anomalies  

Academic Background and Problem Statement Arteriovenous Malformations (AVMs) are benign vascular anomalies prone to pain, bleeding, and progressive growth. The primary cause of AVMs is somatic mutations in the RAS-MAPK signaling pathway. However, not all patients have identifiable causative mutations. To further explore the pathogenesis of AVMs, re...

Prevalence and Clinical Significance of Claudin-3 Expression in Cancer: A Tissue Microarray Study on 14,966 Tumor Samples

Medicine, Obstetrics and Gynecology, Urology, Nephrology, Oncology,
Claudin-3   tissue microarray   cancer   renal cell carcinoma   biomarker  

Prevalence and Clinical Significance of Claudin-3 Expression in Cancer: A Tissue Microarray Study on 14,966 Tumor Samples Academic Background Claudin-3 (Cldn3) is a member of the Claudin family, involved in the formation of tight junctions (TJs), which regulate intercellular permeability. TJs play a crucial role in maintaining the barrier function ...

Advanced Single-Cell and Spatial Analysis with High-Multiplex Characterization of Circulating Tumor Cells and Tumor Tissue in Prostate Cancer: Unveiling Resistance Mechanisms with the CODuco In Situ Assay

Medicine, Urology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Circulating Tumor Cells (CTCs)   Metastatic Prostate Cancer   Multiplex Padlock Probe In Situ Hybridization   Single-Cell Gene Expression   Liquid Biopsy   Spatial Transcriptomics   Neuroendocrine Transdifferentiation  

Research Report on the Academic Paper Title: Advanced Single-Cell and Spatial Analysis with High-Multiplex Characterization of Circulating Tumor Cells and Tumor Tissue in Prostate Cancer: Unveiling Resistance Mechanisms with the CODuco In Situ Assay Authors: Lilli Bonstingl et al. Journal: Biomarker Research (2024) 12:140 DOI: 10.1186/s40364-024-00...

GDF15 Propeptide Promotes Bone Metastasis of Castration-Resistant Prostate Cancer by Augmenting the Bone Microenvironment

Medicine, Urology, Oncology, Life Sciences, Biochemistry,
Castration-Resistant Prostate Cancer   Bone Metastasis   GDF15   Biomarker   Bone Microenvironment  

Research Objective This study aims to identify specific proteins secreted by prostate cancer cells through comprehensive proteomic analysis and explore their role in bone metastasis, with the goal of discovering blood biomarkers that can improve the prognosis of patients with metastatic castration-resistant prostate cancer (mCRPC). Research Team an...