Circulating Tumor DNA-Based Stratification Strategy for Chemotherapy Plus PD-1 Inhibitor in Advanced Non-Small-Cell Lung Cancer

Medicine, Medical Laboratory Science, Oncology, Life Sciences, Immunology,
circulating tumor DNA   chemotherapy   PD-1 inhibitor   non-small-cell lung cancer   personalized treatment  

Exploration of a Chemotherapy and PD-1 Inhibitor Personalized Stratification Strategy Based on Circulating Tumor DNA in Advanced Non-Small Cell Lung Cancer Background and Significance of the Study Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths globally. In the treatment of advanced NSCLC, the combination of immune ...

Distinct Clinical Outcomes and Biological Features of Specific KRAS Mutants in Human Pancreatic Cancer

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Biochemistry, Genetics,
KRAS   mutants   pancreatic cancer   early-stage   clinical outcomes  

Clinical Outcomes and Biological Characteristics Study Report for Pancreatic Cancer Patients with KRAS Mutations Research Background and Objective Pancreatic Ductal Adenocarcinoma (PDAC) is predicted to become the second leading cause of cancer death by 2030. Only about 20% of PDAC patients are eligible for resection surgery, thus the five-year sur...

GABAergic Neuronal Lineage Development Determines Clinically Actionable Targets in Diffuse Hemispheric Glioma

Medicine, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
GABAergic neurons   lineage development   diffuse hemispheric glioma   H3G34 mutation   CDK6   tumor therapy  

Background and Research Objectives High-Grade Glioma (HGG) is a highly lethal primary brain tumor with a particularly high incidence and mortality rate in children and adolescents. HGG can be further divided into several subtypes, among which Diffuse Hemispheric Glioma, H3G34-mutant (DHG-H3G34), is a rare subtype with poor prognosis, mainly occurri...

Glioblastoma Induces the Recruitment and Differentiation of Dendritic-like 'Hybrid' Neutrophils from Skull Bone Marrow

Glioblastoma Induces the Recruitment and Differentiation of Dendritic-like 'Hybrid' Neutrophils from Skull Bone Marrow

Medicine, Neurology, Oncology, Life Sciences, Cell Biology, Immunology,
Glioblastoma   Dendritic Cells   Neutrophils   Skull Bone Marrow   Immunotherapy  

Background Glioblastoma (GBM) is a highly aggressive central nervous system malignancy with very poor prognosis, typically associated with short patient survival. Although significant advancements have been made in tumor treatment technologies and strategies in recent years, traditional radiotherapy and chemotherapy still struggle to achieve satisf...

Effect of Neoadjuvant Chemoradiotherapy with or without PD-1 Antibody Sintilimab in PMMR Locally Advanced Rectal Cancer: A Randomized Clinical Trial

Medicine, Gastroenterology, Oncology, Life Sciences, Immunology,
neoadjuvant chemoradiotherapy   PD-1 antibody   locally advanced rectal cancer   sintilimab   complete response rate  

The Role of Neoadjuvant Chemoradiotherapy Combined or Not Combined with PD-1 Antibody Sintilimab in pMMR Locally Advanced Rectal Cancer: Results of a Randomized Clinical Trial Background and Significance The management of rectal cancer and organ preservation has always been quite challenging, especially in cases of locally advanced rectal cancer (L...

Coagulation Factor X Promotes Resistance to Androgen-Deprivation Therapy in Prostate Cancer

Medicine, Urology, Oncology, Life Sciences, Biochemistry, Immunology,
prostate cancer   androgen-deprivation therapy   coagulation factor X   immunosuppression   tumor microenvironment  

Study on the Role of Coagulation Factor X in Anti-androgen Resistance in Prostate Cancer Research Background Prostate cancer (PCa) is the second most common cancer in men worldwide and is one of the leading causes of cancer-related deaths. The occurrence and progression of prostate cancer are highly dependent on the androgen receptor (AR) signaling...