Systematic Multiomics Analysis and In Vitro Experiments Suggest ITGA5 as a Promising Therapeutic Target for CCRCC

Medicine, Nephrology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
ITGA5   multiomics analysis   clear cell renal cell carcinoma   tumor microenvironment   therapeutic target  

Systematic Multi-Omics Analysis and In Vitro Experiments Suggest ITGA5 as a Potential Target for Clear Cell Renal Cell Carcinoma (ccRCC) Treatment Research Background and Motivation Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC), accounting for about 75% of all kidney cancer cases. According to the ...

Identification and Validation of a Prognostic Model Based on Three TLS-Related Genes in Oral Squamous Cell Carcinoma

Medicine, Oral Sciences, Medical Imaging, Oncology, Life Sciences, Biochemistry, Immunology, Genetics,
oral squamous cell carcinoma   tertiary lymphoid structure   prognostic model   immune infiltration   convolutional neural network  

Research Report: Validation and Analysis of a Prognostic Model for Oral Squamous Cell Carcinoma Constructed with TLS-Related Genes Background and Research Motivation Oral Squamous Cell Carcinoma (OSCC) is the most common subtype of Head and Neck Squamous Cell Carcinoma (HNSCC), exhibiting a high tendency for lymph node metastasis, especially to the...

A Multidimensional Analysis of the Impact of Obesity on Immune Checkpoint Inhibitor Therapy Efficacy

Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Immunology,
obesity   immune checkpoint inhibitors   inflammation   survival rate   cancer  

Background and Research Motivation Obesity has been identified as an important risk factor for various malignancies. It not only promotes the growth and spread of tumor cells but also leads to generally poorer prognosis in patients. However, recent research has found that obese patients receiving immune checkpoint inhibitors (ICI) therapy, especial...

Single-Cell RNA Sequencing and Machine Learning Reveal Relationship Between CD8+ T Cells and Uveal Melanoma Metastasis

Medicine, Oncology,
single-cell RNA sequencing   uveal melanoma   metastasis risk   immune microenvironment   CD8+ T cells   machine learning   tumor microenvironment  

Academic Report on “Machine Learning and Single-cell RNA Sequencing Reveal Relationship Between Intratumor CD8+ T Cells and Uveal Melanoma Metastasis” published in Cancer Cell International in 2024 Research Background and Purpose Uveal melanoma (UM) is the most common intraocular malignant tumor in adults. After receiving radiation or surgical trea...

Targeting HSP90AB1 and PARP1 to Enhance Anticancer Therapy in Prostate Cancer

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry,
prostate cancer   HSP90AB1   PARP1   olaparib   cell survival   PI3K/AKT pathway   combination therapy  

Therapeutic Potential of Synergistic Targeted Inhibition of HSP90AB1 and PARP1 in Prostate Cancer Cells: A Review of Celastrol and Olaparib Combination Therapy Background Prostate Cancer (PCA) is one of the most common malignancies among men worldwide, with its incidence continually rising in recent years, making early screening and treatment cruci...

Study on the Apoptosis Induction of Bladder Cancer Stem Cells by Inhibiting Stearoyl-CoA Desaturase

Medicine, Urology, Oncology, Life Sciences, Cell Biology, Biochemistry,
bladder cancer   stearoyl-CoA desaturase   cancer stem cells   lipid metabolism   apoptosis  

Research Background Bladder cancer is a highly prevalent malignant tumor worldwide, ranking as the fourth most common malignancy in men. According to the 2016 report by the National Cancer Center of China (NCCR), bladder cancer ranks sixth in incidence among male malignancies. Despite continuous improvements in medical diagnostic methods and surgic...