Effect on Travel Distance of a Statewide Regionalization Policy for Initial Breast Cancer Surgery

Medicine, Oncology,
breast cancer   regionalization policy   travel distance   New York State   Medicaid  

The Impact of a Statewide Regionalization Policy on Travel Distance for Initial Breast Cancer Surgery Academic Background Breast cancer is one of the most common cancers among women globally, and the quality of treatment and patient survival rates are closely related to the allocation of medical resources. Studies have shown that high-volume medica...

Single or Double Induction with 7+3 Containing Standard or High-Dose Daunorubicin for Newly Diagnosed AML: The Randomized DAUNODouble Trial by the Study Alliance Leukemia

Medicine, Hematology, Oncology,
Acute Myeloid Leukemia   Induction Therapy   Randomized Controlled Trial   Daunorubicin   Survival Rate  

Academic Background Acute Myeloid Leukemia (AML) is a malignant blood disorder, with the core of its treatment being induction chemotherapy, typically involving a combination of cytarabine and anthracyclines (such as daunorubicin). Although this treatment regimen has been in use since the 1980s, questions regarding the optimal dose of daunorubicin ...

Revumenib for KMT2A-Rearranged Relapsed or Refractory Acute Leukemia: Efficacy and Safety

Medicine, Hematology, Oncology,
Revumenib   KMT2A-rearranged   acute leukemia   relapsed   refractory   safety   efficacy  

Academic Background Acute leukemia is a malignant hematologic disease caused by genetic mutations in hematopoietic cells, characterized by a block in differentiation during hematopoiesis and uncontrolled cellular proliferation. Among these, KMT2A gene rearrangements (KMT2A-rearranged, KMT2Ar) occur in up to 10% of acute leukemias in children and ad...

Efficacy and Safety of Darolutamide in Combination with Androgen-Deprivation Therapy in Patients with Metastatic Hormone-Sensitive Prostate Cancer

Medicine, Urology, Oncology,
Darolutamide   Androgen-Deprivation Therapy   Metastatic Hormone-Sensitive Prostate Cancer   Radiological Progression-Free Survival   Safety  

Darolutamide in Combination with Androgen-Deprivation Therapy in Patients with Metastatic Hormone-Sensitive Prostate Cancer from the Phase III ARANOTE Trial Academic Background Metastatic hormone-sensitive prostate cancer (mHSPC) is a common type of prostate cancer. Patients typically respond to androgen-deprivation therapy (ADT) for a period of ti...

Whole Lung Irradiation in Rhabdomyosarcoma with Lung Metastases: A Report from the Soft Tissue Sarcoma Committee of the Children’s Oncology Group

Medicine, Pediatrics, Oncology,
rhabdomyosarcoma   lung metastases   whole lung irradiation   Children’s Oncology Group   survival rate  

Efficacy of Whole Lung Irradiation in Rhabdomyosarcoma with Lung Metastases Academic Background Rhabdomyosarcoma (RMS) is a common soft tissue sarcoma in children. Despite advancements in treatment, the prognosis for patients with metastatic RMS remains poor, especially for those with lung metastases, whose survival rates are significantly lower th...

Revumenib Revises the Treatment Landscape for KMT2A-R Leukemia

Medicine, Hematology, Oncology,
Revumenib   KMT2A-R leukemia   menin inhibitors   gene expression   clinical trial   leukemia cell differentiation   drug resistance  

Revumenib Alters the Treatment Landscape for KMT2A-Rearranged Leukemia Academic Background Leukemia is a malignant disease caused by abnormalities in the hematopoietic system, with KMT2A-rearranged (KMT2A-r) leukemia being a common subtype, particularly in pediatric and adult acute myeloid leukemia (AML). Rearrangements of the KMT2A gene (lysine me...