Retinal Pigment Epithelial Cells Reduce Vascular Leak and Proliferation in Retinal Neovessels

Medicine, Ophthalmology,
Epithelial-Mesenchymal Transition   Neovascularization   Macular Telangiectasia Type 2   Pigment Migration   Vascular Leakage   Retinal Imaging  

Retinal Pigment Epithelial Cells Reduce Vascular Leak and Proliferation in Retinal Neovessels Academic Background Retinal pigment epithelial cells (RPE cells) play a crucial role in various functions of the retina, including responding to stress and damage in the neuroretina. In many neurodegenerative diseases, such as age-related macular degenerat...

Prevalence and Clinical Significance of Claudin-3 Expression in Cancer: A Tissue Microarray Study on 14,966 Tumor Samples

Medicine, Obstetrics and Gynecology, Urology, Nephrology, Oncology,
Claudin-3   tissue microarray   cancer   renal cell carcinoma   biomarker  

Prevalence and Clinical Significance of Claudin-3 Expression in Cancer: A Tissue Microarray Study on 14,966 Tumor Samples Academic Background Claudin-3 (Cldn3) is a member of the Claudin family, involved in the formation of tight junctions (TJs), which regulate intercellular permeability. TJs play a crucial role in maintaining the barrier function ...

Advanced Single-Cell and Spatial Analysis with High-Multiplex Characterization of Circulating Tumor Cells and Tumor Tissue in Prostate Cancer: Unveiling Resistance Mechanisms with the CODuco In Situ Assay

Medicine, Urology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Circulating Tumor Cells (CTCs)   Metastatic Prostate Cancer   Multiplex Padlock Probe In Situ Hybridization   Single-Cell Gene Expression   Liquid Biopsy   Spatial Transcriptomics   Neuroendocrine Transdifferentiation  

Research Report on the Academic Paper Title: Advanced Single-Cell and Spatial Analysis with High-Multiplex Characterization of Circulating Tumor Cells and Tumor Tissue in Prostate Cancer: Unveiling Resistance Mechanisms with the CODuco In Situ Assay Authors: Lilli Bonstingl et al. Journal: Biomarker Research (2024) 12:140 DOI: 10.1186/s40364-024-00...

GDF15 Propeptide Promotes Bone Metastasis of Castration-Resistant Prostate Cancer by Augmenting the Bone Microenvironment

Medicine, Urology, Oncology, Life Sciences, Biochemistry,
Castration-Resistant Prostate Cancer   Bone Metastasis   GDF15   Biomarker   Bone Microenvironment  

Research Objective This study aims to identify specific proteins secreted by prostate cancer cells through comprehensive proteomic analysis and explore their role in bone metastasis, with the goal of discovering blood biomarkers that can improve the prognosis of patients with metastatic castration-resistant prostate cancer (mCRPC). Research Team an...

FBXL16: A New Regulator of Neuroinflammation and Cognition in Alzheimer’s Disease through the Ubiquitination-Dependent Degradation of Amyloid Precursor Protein

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
FBXL16   ubiquitination   Alzheimer’s disease   neuroprotection   amyloid precursor protein  

FBXL16: A New Regulator of Neuroinflammation and Cognition in Alzheimer’s Disease through Ubiquitination-Dependent Degradation of Amyloid Precursor Protein Academic Background Alzheimer’s Disease (AD) is an age-related neurodegenerative disorder characterized by progressive cognitive decline. With the global aging population, the incidence of neuro...

Global Surveillance of Circulating MicroRNA for Diagnostic and Prognostic Assessment of Acute Myocardial Infarction Based on Plasma Small RNA Sequencing

Medicine, Cardiovascular System,
Acute Myocardial Infarction   Circulating MicroRNA   Diagnosis   Prognosis   Plasma Small RNA Sequencing   Biomarkers   Global Surveillance  

Global Surveillance of Circulating MicroRNA for Diagnostic and Prognostic Assessment of Acute Myocardial Infarction Based on Plasma Small RNA Sequencing Academic Background Acute Myocardial Infarction (AMI) is one of the most severe cardiovascular diseases leading to human mortality and morbidity worldwide. The pathological mechanism of AMI primari...