Global Surveillance of Circulating MicroRNA for Diagnostic and Prognostic Assessment of Acute Myocardial Infarction Based on Plasma Small RNA Sequencing

Medicine, Cardiovascular System,
Acute Myocardial Infarction   Circulating MicroRNA   Diagnosis   Prognosis   Plasma Small RNA Sequencing   Biomarkers   Global Surveillance  

Global Surveillance of Circulating MicroRNA for Diagnostic and Prognostic Assessment of Acute Myocardial Infarction Based on Plasma Small RNA Sequencing Academic Background Acute Myocardial Infarction (AMI) is one of the most severe cardiovascular diseases leading to human mortality and morbidity worldwide. The pathological mechanism of AMI primari...

BRD4 Inhibitor Reduces Exhaustion and Blocks Terminal Differentiation in CAR-T Cells by Modulating BATF and EGR1

Medicine, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
CAR-T cell exhaustion   BRD4 inhibitor   single-cell RNA sequencing   transcriptional factors   acute myeloid leukemia  

Acute myeloid leukemia (AML) is the most common type of leukemia in adults. Although most AML patients achieve complete remission after standard chemotherapy, refractory and relapsed disease remain a significant challenge. Over the past decade, immunotherapy has been widely applied in cancer treatment, particularly chimeric antigen receptor T-cell ...

Skin-Permeable Gold Nanoparticles with Azelamide Monoethanolamine Modifications Ameliorate Inflammatory Skin Diseases

Chemistry, Nanoscience, Medicinal Chemistry, Materials Science, Medicine, Rheumatology and Immunology, Life Sciences, Immunology,
gold nanoparticles   azelamide monoethanolamine   skin inflammation   topical therapeutics   oxidative stress   matrix metalloproteinase   superoxide dismutase  

Report on the Academic Paper Inflammatory skin diseases, such as psoriasis and rosacea, are common chronic skin conditions worldwide, significantly impacting patients’ quality of life. Traditional topical drug delivery methods, while simple and non-invasive, suffer from poor skin penetration and long-term side effects. Therefore, developing an effe...

Exosomal PSM-E Inhibits Macrophage M2 Polarization to Suppress Prostate Cancer Metastasis Through the RACK1 Signaling Axis

Medicine, Urology, Oncology,
prostate cancer   exosomes   macrophage polarization   RACK1 signaling pathway   tumor microenvironment  

Exosomal PSM-E Inhibits Macrophage M2 Polarization to Suppress Prostate Cancer Metastasis via the RACK1 Signaling Axis Academic Background Prostate cancer (PCA) is a prevalent cancer among men and the second leading cause of cancer-related deaths. While early-stage prostate cancer can be treated with surgery or radiotherapy, approximately one-third...

Single-Cell Analysis Reveals Alterations Between the Aged and Young Mice Prostates

Medicine, Urology, Life Sciences, Cell Biology, Immunology,
Single-cell RNA sequencing   Prostate aging   Cellular heterogeneity   Gene expression   Mouse model  

Single-Cell Analysis Reveals Differences Between Aged and Young Mouse Prostates Academic Background The prostate is a vital component of the male reproductive system. As men age, the prostate undergoes hyperplasia, which can lead to urethral compression, resulting in voiding dysfunction and associated symptoms, as well as an increased risk of prost...

Validation of a Prognostic Blood-Based Sphingolipid Panel for Men with Localized Prostate Cancer Followed on Active Surveillance

Medicine, Urology, Oncology,
sphingolipids   prostate cancer   active surveillance   biomarkers   risk stratification  

Study on a Prognostic Blood-Based Sphingolipid Panel for Men with Localized Prostate Cancer on Active Surveillance Academic Background Prostate cancer is one of the most common cancers among men globally, particularly for those with low- and intermediate-risk prostate cancer, where active surveillance (AS) has become the preferred management strate...