Academic Background The formation and maintenance of vascular networks are critical processes in embryonic development and tissue regeneration, involving the regulation of various biophysical forces. Endothelial cells (ECs) play a central role in angiogenesis and vasculogenesis, with the contractile forces of the cytoskeleton (actomyosin contractil...
Academic Background The placenta plays a critical role in health and disease during pregnancy, and its development and function directly impact pregnancy outcomes. The early development of the utero-placental vasculature is essential for ensuring normal placental function, while abnormal vascular development is closely associated with placenta-rela...
Academic Background and Problem Statement Retinopathy of Prematurity (ROP) is a common retinal neurovascular disorder in premature infants, primarily occurring in those whose retinal vascular development is incomplete. Due to exposure to a relatively hyperoxic environment after birth, especially with supplemental oxygen therapy, hyperoxia suppresse...
Research Background Alzheimer’s Disease (AD) is a common neurodegenerative disorder characterized by the deposition of amyloid-beta (Aβ) plaques and abnormal phosphorylation of tau protein. Recent studies have increasingly highlighted the role of cerebrovascular alterations in the pathogenesis of AD. Specifically, endothelial cell damage and inflam...
Report on the Study of Inflammasome Activation Aggravating Choroidal Neovascularization Academic Background Age-related macular degeneration (AMD) is a common retinal disease, particularly among the elderly. AMD is divided into dry and wet types, with wet AMD characterized by choroidal neovascularization (CNV), where abnormal blood vessels grow fro...
Retinal Pigment Epithelial Cells Reduce Vascular Leak and Proliferation in Retinal Neovessels Academic Background Retinal pigment epithelial cells (RPE cells) play a crucial role in various functions of the retina, including responding to stress and damage in the neuroretina. In many neurodegenerative diseases, such as age-related macular degenerat...