PNPO-PLP Axis Senses Prolonged Hypoxia in Macrophages by Regulating Lysosomal Activity

Oxygen is an essential substance for all metazoan organisms on Earth, influencing biological processes under various physiological and pathological conditions. Although systems that induce acute hypoxic responses, including the hypoxia-inducible factor (HIF) pathway, have been identified, their mechanisms of action under prolonged hypoxia remain in...

Time of Exercise Differentially Impacts Bone Growth in Mice

Differential Effects of Exercise Timing on Skeletal Growth in Mice Introduction Skeletal growth is crucial for adult height and bone health. Studies have shown that exercise can effectively increase bone density, but the optimal exercise timing remains unclear. This study aimed to investigate the optimal exercise timing by comparing the effects of ...

Injectable Ultrasonic Sensor for Wireless Monitoring of Intracranial Signals

Injectable Ultrasonic Sensor for Wireless Monitoring of Intracranial Signals

Wireless Injectable Ultrasound Sensor for Intracranial Signal Monitoring Background Introduction Direct and accurate monitoring of intracranial physiological conditions is extremely important for injury classification, prognosis assessment, and disease prevention. However, traditional wired clinical devices, such as percutaneous leads, although per...

A Novel CNN-Based Image Segmentation Pipeline for Individualized Feline Spinal Cord Stimulation Modeling

Automated Spinal Cord Segmentation Pipeline Based on Convolutional Neural Network (CNN) for Individualized Cat Spinal Cord Stimulation Modeling Background and Research Motivation Spinal cord stimulation (SCS) is a widely used treatment method for chronic pain management. In recent years, it has also been used to modulate neural activity, aiming to ...

Attention-Guided Graph Structure Learning Network for EEG-enabled Auditory Attention Detection

Attention-Guided Graph Structure Learning Network for EEG-enabled Auditory Attention Detection

Application of Attention-guided Graph Structure Learning Network for EEG-enabled Auditory Attention Detection Academic Background The “cocktail party effect” describes the human brain’s ability to selectively concentrate attention on one speaker while ignoring others in a multi-talker environment. However, for individuals with hearing impairments, ...

Feasibility of Endovascular Stimulation of the Femoral Nerve Using a Stent-Mounted Electrode Array

Feasibility of Intravascular Femoral Nerve Stimulation using a Stent Electrode Array In recent years, electrical stimulation of peripheral nerves has gained attention as a potential therapeutic approach for restoring impaired nerve function. Traditional electrode arrays typically require invasive surgical implantation, which imposes a significant b...