Fixel-Based Analysis Reveals Tau-Related White Matter Changes in Early Stages of Alzheimer’s Disease

Medicine, Neurology, Life Sciences, Biochemistry,
Alzheimer’s disease   diffusion tensor imaging   fixel-based analysis   memory   white matter  

Report: Revealing White Matter Changes Associated with Tau in Early Alzheimer’s Disease through Fixel-based Analysis Research Background Alzheimer’s Disease (AD) is generally thought to primarily affect the grey matter (GM), but more and more evidence shows that the white matter (WM) also experiences abnormalities. Current research largely relies o...

Development and Standardization of an Osteoradionecrosis Classification System in Head and Neck Cancer: Implementation of a Risk-Based Model

Medicine, Oncology,
head and neck cancer   osteoradionecrosis   classification system   radiation therapy   risk factors  

Development and Standardization of an Osteoradionecrosis Classification System in Head and Neck Cancer: Implementation Based on Risk Model In recent years, the side effects brought by the treatment of head and neck cancer (HNC), especially radiotherapy, have become a focal point of academic attention. Osteoradionecrosis (ORN) is one of the most sev...

Clinical and Genomic-Based Decision Support System to Define the Optimal Timing of Allogeneic Hematopoietic Stem-Cell Transplantation in Patients with Myelodysplastic Syndromes

Clinical and Genomic-Based Decision Support System to Define the Optimal Timing of Allogeneic Hematopoietic Stem-Cell Transplantation in Patients with Myelodysplastic Syndromes

Medicine, Hematology, Oncology, Life Sciences, Genetics,
Myelodysplastic Syndromes   Allogeneic Hematopoietic Stem-Cell Transplantation   Decision Support System   Clinical and Genomic Information   Prognostic Scoring System   Personalized Therapy  

Background Myelodysplastic Syndromes (MDS) are a group of heterogeneous diseases originating from bone marrow hematopoietic stem cells, characterized by reduced blood cell production. Although certain progress in treatment has been made in recent years, allogeneic hematopoietic stem-cell transplantation (HSCT) remains the only potentially curative ...

Intimate Care Products and Incidence of Hormone-Related Cancers: A Quantitative Bias Analysis

Medicine, Nursing, Environmental and Public Health, Oncology,
Intimate Care Products   Hormone-Related Cancers   Genital Talc   Douching   Recall Bias   Exposure Misclassification   US Cohort Study  

Incidence of Hormone-Related Cancers and Intimate Care Products Introduction In recent years, there has been an increasing concern about the safety of intimate care products that may contain potential endocrine disrupting chemicals, such as phthalates, parabens, and bisphenols. These chemicals are believed to alter endogenous hormone levels, influe...

Feasibility of Electronic Patient-Reported Outcomes in Older Cancer Patients

Medicine, Environmental and Public Health, Oncology,
electronic patient-reported outcomes   older patients   cancer care   remote monitoring   quality of life   technological barriers  

Multicenter Prospective Study: Feasibility of Electronic Patient-Reported Outcomes (ePROs) in Elderly Cancer Patients Research Background In recent years, telemedicine has developed rapidly, especially during the COVID-19 pandemic, and is considered a solution to the problem of medical personnel shortages. Electronic patient-reported outcomes (ePRO...

Self-Supervised Deep Learning-Based Denoising for Diffusion Tensor MRI

Self-Supervised Deep Learning-Based Denoising for Diffusion Tensor MRI

Medicine, Medical Imaging, Life Sciences, Bioengineering,
self-supervised learning   deep learning   convolutional neural network   diffusion tensor imaging   denoising  

Background Introduction Diffusion Tensor Magnetic Resonance Imaging (DTI) is a widely used neuroimaging technique for imaging the microstructure of brain tissues and white matter tracts. However, noise in Diffusion-Weighted Images (DWI) can reduce the accuracy of microstructural parameters derived from DTI data and also necessitate longer acquisiti...