NMDA Receptor Autoantibodies Primarily Impair the Extrasynaptic Compartment

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Biochemistry, Immunology,
autoantibody   encephalitis   extrasynaptic NMDA receptor   membrane proteins   interactome  

NMDA Receptor Autoantibodies Mainly Damage Extrasynaptic Components Background Information In recent years, neuroimmunology research has revealed various neurological and psychiatric diseases associated with autoantibodies. In these disorders, autoantibodies target various molecules, including receptor membrane proteins, causing abnormal neural sys...

Distinct Ultrastructural Phenotypes of Glial and Neuronal Alpha-Synuclein Inclusions in Multiple System Atrophy

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Neurology,
multiple system atrophy   glial cells   neurons   alpha-synuclein   ultrastructure   pathology   human brain  

Different Ultrastructural Phenotypes of α-Synuclein Inclusions in Glia and Neurons in Brain Regions of Multiple System Atrophy (MSA) Introduction Multiple System Atrophy (MSA) is a severe neurodegenerative disease characterized by abnormal accumulation of α-Synuclein (α-Syn) in specific brain regions, forming pathological inclusions that primarily ...

Connectome Reorganization Associated with Temporal Lobe Pathology and Its Surgical Resection

Connectome Reorganization Associated with Temporal Lobe Pathology and Its Surgical Resection

Medicine, Neurology, Neurosurgery, Medical Imaging,
connectome   brain networks   focal lesion   surgery   longitudinal   gradients  

Connectomics Reconstruction Associated with Temporal Lobe Lesions and Their Surgical Resection Academic Background The human brain’s structural organization is increasingly conceptualized and analyzed from a network perspective, greatly enhancing understanding of health and disease. In recent years, thanks to advances in neuroimaging technology and...

KATP Channel Mutation Disrupts Hippocampal Network Activity and Nocturnal Gamma Shifts

Medicine, Basic Medical Sciences, Neurology,
DEND syndrome   KATP channel   parvalbumin-positive interneuron   sharp wave ripples   gamma oscillations   epilepsy  

KATP Channel Mutation Disrupts Hippocampal Network Activity and Nocturnal Gamma Wave Changes Research Background ATP-sensitive potassium (KATP) channels are crucial ion channels that link cellular metabolism with electrical activity. Studies have shown that high activity of KATP channels is closely related to a rare disease—Developmental delay, Epi...

Single-Value Brain Activity Scores Reflect Both Severity and Risk Across the Alzheimer’s Continuum

Medicine, Neurology, Medical Imaging,
Single-value scores   Brain activity   Alzheimer's disease   Memory impairment   Imaging biomarkers   Mild cognitive impairment   Diagnostic markers  

Report on the Association Between Single Value Brain Activity Scores and the Progression of Alzheimer’s Disease Introduction Among the elderly population, cognitive decline and brain structural changes are widespread, even among healthy individuals1-3. Episodic memory, crucial for storing, maintaining, and retrieving single-event memories4, is espe...

Low-Intensity Ultrasound Ameliorates Brain Organoid Integration and Rescues Microcephaly Deficits

Medicine, Pediatrics, Basic Medical Sciences, Neurology, Neurosurgery, Life Sciences, Bioengineering, Biophysics,
brain organoid   low-intensity ultrasound   neural progenitor cells   microcephaly   circuit integration  

Low-intensity Ultrasound Promotes Brain Organoid Integration and Improves Microcephaly Defects Background of the Study Brain organoids are generated through the differentiation of pluripotent stem cells (PSCs) and exhibit impressive cellular diversity, capable of mimicking functional networks similar to the human brain. These organoid methods hold ...