Low-Intensity Ultrasound Ameliorates Brain Organoid Integration and Rescues Microcephaly Deficits

Medicine, Pediatrics, Basic Medical Sciences, Neurology, Neurosurgery, Life Sciences, Bioengineering, Biophysics,
brain organoid   low-intensity ultrasound   neural progenitor cells   microcephaly   circuit integration  

Low-intensity Ultrasound Promotes Brain Organoid Integration and Improves Microcephaly Defects Background of the Study Brain organoids are generated through the differentiation of pluripotent stem cells (PSCs) and exhibit impressive cellular diversity, capable of mimicking functional networks similar to the human brain. These organoid methods hold ...

Mapping Interictal Discharges Using Intracranial EEG-fMRI to Predict Postsurgical Outcomes

Mapping Interictal Discharges Using Intracranial EEG-fMRI to Predict Postsurgical Outcomes

Medicine, Neurology, Neurosurgery, Medical Imaging, Life Sciences, Biophysics,
epilepsy   surgery   electroencephalography   imaging   seizures   markers  

Using Intracranial EEG-fMRI Mapping of Intermittent Discharges to Predict Epilepsy Surgery Outcomes Background and Objective Epilepsy is a common neurological disorder, and many patients are unresponsive to pharmacological treatments, making surgery one of the primary therapeutic options. However, accurately localizing the seizure onset zone (SOZ) ...

Distinct Virtual Histology of Grey Matter Atrophy in Four Neuroinflammatory Diseases

Medicine, Rheumatology and Immunology, Neurology, Medical Imaging, Life Sciences, Immunology, Biophysics,
virtual histology   grey matter atrophy   multiple sclerosis   NMOSD   MOGAD  

Research Background The core focus of this study is the manifestation of gray matter atrophy in neuroinflammatory diseases. Gray matter atrophy typically appears in four types of neuroinflammatory demyelinating diseases: Multiple Sclerosis (MS), Neuromyelitis Optica Spectrum Disorders (NMOSD) positive (AQP4+) and negative (AQP4-) for aquaporin-4 an...

Meso-Cortical Pathway Damage in Cognition, Apathy, and Gait in Cerebral Small Vessel Disease

Medicine, Neurology, Medical Imaging,
Small Vessel Disease   Cognitive Impairment   Apathy   Gait Dysfunction   Neural Pathways  

Impact of Midbrain-Cortical Pathway Damage on Cognition, Apathy, and Gait in Small Vessel Disease Background and Research Motivation Small Vessel Disease (SVD) is a complex brain disorder mainly involving various pathological changes in small brain vessels, such as White Matter Hyperintensities (WMH), lacunar infarctions, and cerebral microbleeds. ...

Transient Brain Structure Changes After High Phenylalanine Exposure in Adults with Phenylketonuria

Medicine, Pediatrics, Neurology, Medical Imaging,
Phenylketonuria   Surface-based morphometry   Cognition   Intervention   Randomized controlled trial   Recovery  

The Impact of High Phenylalanine Exposure on Brain Structure in Adult Phenylketonuria Patients Background Phenylketonuria (PKU) is a rare hereditary metabolic disorder characterized by a deficiency of phenylalanine hydroxylase, leading to elevated levels of phenylalanine (Phe) in the blood and brain. If Phe levels are not strictly controlled during...

Genetics Impact Risk of Alzheimer's Disease through Mechanisms Modulating Structural Brain Morphology in Late Life

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Genetics,
Alzheimer's disease   genetics   brain morphology  

In recent years, Alzheimer’s disease (AD) has become a significant health problem affecting the elderly population worldwide. Its related neuropathological changes can begin decades before the appearance of clinical symptoms. To explore more comprehensively the relationship between AD risk and brain morphology, a research team conducted a bidirecti...