Ketones in Cellular Physiology: Metabolic, Signaling, and Therapeutic Advances

Medicine, Sports Medicine, Life Sciences, Biochemistry,
ketones   metabolism   signaling   therapeutics   low-carbohydrate diet   endurance exercise   hypoglycemia prevention  

Research Report: The Role of Ketones in Cellular Physiology: Metabolic, Signaling, and Therapeutic Advances Academic Background For a long time, carbohydrate (CHO) intake has been considered a key factor in enhancing athletic performance during endurance exercise. The traditional view holds that a high-carbohydrate low-fat diet (HCLF) can increase ...

The Role of KV7 Channels in Modulating Tension and Calcium Signaling in Mouse Corpus Cavernosum

Medicine, Basic Medical Sciences, Urology,
KV7 channels   corpus cavernosum   calcium signaling   tension   erectile dysfunction  

Study on the Role of KV7 Channels in Regulating Smooth Muscle Contraction in Mouse Corpus Cavernosum Academic Background Erectile dysfunction (ED) is a significant health issue that impacts the quality of life for men. Since the introduction of phosphodiesterase 5 (PDE5) inhibitors like Sildenafil in the 1990s, there has been notable progress in th...

Estrogen Deficiency Alters Vascularization and Mineralization Dynamics: Insight from a Novel 3-D Humanized and Vascularized Bone Organoid Model

Medicine, Orthopedics, Endocrinology, Life Sciences, Bioengineering,
osteoporosis   vascularization   mineralization   3D model   estrogen deficiency  

The Impact of Estrogen Deficiency on Vascularization and Mineralization Dynamics—Insights from a Novel 3D Humanized and Vascularized Bone Organoid Model Academic Background Osteoporosis is a common bone disease, particularly prevalent among postmenopausal women. Osteoporosis not only manifests as a reduction in bone mass but also involves changes i...

CDC42 is crucial for the early regulation of hepatic stellate cell activation

Medicine, Hepatobiliary System, Gastroenterology, Life Sciences, Cell Biology, Biochemistry, Immunology,
hepatic stellate cells   liver fibrosis   morphological alterations   CDC42   cell cycle  

CDC42 Plays a Crucial Role in the Early Regulation of Hepatic Stellate Cell Activation Academic Background Liver fibrosis is a pathological process associated with various liver diseases, which may eventually progress to cirrhosis—a life-threatening condition. Currently, there are no effective treatments to halt the progression of liver fibrosis. H...

Increasing Cellular NAD+ Protects Hepatocytes Against Palmitate-Induced Lipotoxicity

Medicine, Hepatobiliary System, Gastroenterology, Life Sciences, Biochemistry,
lipotoxicity   PARP-1   mTORC1   NAD+   hepatocyte protection  

NAD+ Protects Hepatocytes Against Palmitate-Induced Lipotoxicity by Preventing PARP-1 Inhibition and mTORC1-p300 Pathway Activation Research Background Metabolic dysfunction-associated fatty liver disease (MAFLD) encompasses a spectrum of liver diseases ranging from simple steatosis to steatohepatitis, fibrosis/cirrhosis, and even hepatocellular ca...

O-GlcNAcylation Regulates Tyrosine Hydroxylase Serine 40 Phosphorylation and L-Dopa Levels

Medicine, Neurology, Life Sciences, Biochemistry,
O-GlcNAcylation   Tyrosine Hydroxylase   Serine 40 Phosphorylation   L-Dopa   Neurotransmitter  

O-GlcNAcylation Regulates Tyrosine Hydroxylase Serine 40 Phosphorylation and L-DOPA Levels Research Background In the nervous system, dopamine is a key neurotransmitter, and the rate-limiting enzyme in its synthesis pathway is tyrosine hydroxylase (TH). The activity of TH is regulated by various post-translational modifications (PTMs), among which ...