TREM2 Deficiency Remodels Intestinal Macrophages and Microbiota to Enhance Anti-PD-1 Tumor Immunotherapy A research team from the Washington University School of Medicine, led by Blanda Di Luccia and other scientists, recently published a study in the journal Science Immunology, revealing how intestinal microbiota and tumor-associated macrophages i...
Immunoglobulin Superfamily Ligand B7H6 Enables T Cell Responses under NK Cell Surveillance Background In the field of immunology, understanding the mechanisms regulating T cell immunity is crucial for developing effective therapies for diseases related to T cell dysfunction, such as autoimmune diseases, chronic infections, and cancer. T cells media...
Major Breakthrough in Research for Autoimmune Neuroinflammation Treatment Background Introduction Steroid resistance is a significant challenge in the treatment of many inflammatory diseases, particularly autoimmune neuroinflammation. In these diseases, TH17 cells (T helper 17 cells) are widely regarded as key contributors to steroid resistance; ho...
Immunotherapy Checkpoint Inhibitors (ICIs, also known as immune checkpoint blockers) are a class of drugs that have achieved significant breakthroughs in cancer immunotherapy in recent years. These drugs mainly work by blocking Programmed Death Protein 1 (PD-1) and Cytotoxic T-lymphocyte-associated Protein 4 (CTLA-4), thereby activating anti-tumor ...
The Effect of Nudcd3 Deficiency on V(D)J Recombination In the study of congenital immunodeficiency, especially in the field of T cell developmental abnormalities, identifying key genes and pathways is of great significance. Researches on Severe Combined Immunodeficiency (SCID) and Omenn Syndrome (OS) have highlighted the crucial roles of T cell rec...
Background Introduction The immune system plays a crucial role in responding to viral infections, and T cell memory is especially important in secondary immune responses. This paper focuses on how resident memory T cells (LN TRMs) in lymph nodes are formed after skin infections. LN TRMs play a key role in immune memory at specific sites, but their ...