Microglial AKAP8L: A Key Mediator in Diabetes-Associated Cognitive Impairment via Autophagy Inhibition and Neuroinflammation Triggering

Medicine, Rheumatology and Immunology, Neurology, Life Sciences, Immunology,
AKAP8L   mTOR   Diabetes-Associated Cognitive Impairment   Microglia   Autophagy   Neuroinflammation  

Key Mediator Akap8l in Microglia for Diabetes-Associated Cognitive Impairment: Functions via Autophagy Inhibition and Neuroinflammation Academic Background In recent years, diabetes-associated cognitive impairment (DACI) has received increasing attention. It not only poses a threat to the self-management capabilities of diabetic patients but also i...

Inflammatory Mechanisms in Traumatic Brain Injury and Post-Traumatic Epilepsy: A Study

Medicine, Rheumatology and Immunology, Neurology, Neurosurgery, Life Sciences, Biochemistry, Immunology,
Traumatic Brain Injury   Post-Traumatic Epilepsy   Inflammasome Signaling   Microglia   NLRP3  

Neuroinflammation and Epilepsy: The Role of Inflammasomes in Traumatic Brain Injury Background and Purpose Traumatic Brain Injury (TBI) refers to changes in brain function and pathology resulting from physical trauma to the head or neck. Apart from common behavioral and psychological disorders, post-traumatic epilepsy (PTE) is one of the most sever...

Early Depletion of Gut Microbiota Shapes Oligodendrocyte Response After Traumatic Brain Injury

Medicine, Rheumatology and Immunology, Neurology, Neurosurgery, Life Sciences, Cell Biology, Immunology, Microbiology,
Traumatic Brain Injury   White Matter Injury   Gut Microbiota   T Cells   Oligodendrocytes   Neuroinflammation   Remyelination  

Study on the Role of Gut Microbiota in White Matter Repair after Traumatic Brain Injury - Analysis of “Journal of Neuroinflammation” Introduction Every year, around 1.7 million people in the United States experience traumatic brain injury (TBI), with over 5 million facing disability issues related to TBI. These non-fatal TBIs are estimated to incur...

Systemic Administration of Soluble Glycoprotein 130 in Traumatic Brain Injury: Effects on Cognitive Performance and Chemokine Levels

Medicine, Rheumatology and Immunology, Medical Laboratory Science, Neurology, Neurosurgery, Life Sciences, Immunology,
Traumatic Brain Injury   Soluble Glycoprotein 130   Cognitive Performance   Chemokine Levels   Neuroinflammation  

Research Review: Treating Traumatic Brain Injury through Selective Inhibition of IL-6 Pathway Background Traumatic brain injury (TBI) is one of the leading causes of long-term neurological damage and death globally, with no effective disease-modifying treatments currently available. TBI patients often suffer from cognitive, behavioral, and sensory ...

The Molecular Regulation of Astroglia-Driven Neuroinflammation in Experimental Glaucoma

Medicine, Rheumatology and Immunology, Neurology, Ophthalmology, Life Sciences, Immunology,
astroglia   CFliP   cytokine   glaucoma   neuroinflammation  

Research Background Glaucoma is a major cause of blindness, characterized by complex neurodegenerative conditions that include extensive inflammatory responses in glial cells, accompanied by the progressive loss of Retinal Ganglion Cells (RGCs), optic nerve axons, and synaptic connections. Although there are variations in subtypes, topologies, and ...

Differences in the Characteristics and Functions of Brain and Spinal Cord Regulatory T Cells

Medicine, Rheumatology and Immunology, Neurology, Life Sciences, Immunology,
Regulatory T cells   Autoimmune diseases   Brain   Spinal cord   Tissue-specificity   Inflammation suppression   Immune tolerance  

Research Report: Differential Characteristics and Functions of Regulatory T Cells in the Brain and Spinal Cord Research Background and Motivation This study explored the characteristics and functional differences of regulatory T cells (Tregs) within the central nervous system (CNS). Tregs play a key role in the adaptive immune response, primarily b...