Astrocytic Stress Response Induced by Exposure to Astrocyte-Binding Antibodies in Pediatric Acute Transverse Myelitis Cases

Medicine, Pediatrics, Rheumatology and Immunology, Neurology, Hematology, Life Sciences, Immunology,
Pediatric   Acute Transverse Myelitis   Astrocytes   Antibodies   Neuroinflammation  

B-cell Response in Pediatric Acute Transverse Myelitis Acute transverse myelitis (ATM) is an autoimmune-mediated inflammatory disease of the spinal cord with an incidence of 1.7-2 cases per million children per year. ATM typically presents with limb weakness, sensory loss, and bladder/bowel dysfunction, with symptoms rapidly developing over hours t...

Study on the Effects of Traumatic Brain Injury on Chronic Meningeal CLIP+ B Cells, Neuropathology, and Neurobehavioral Impairment in 5xFAD Mice

Medicine, Rheumatology and Immunology, Neurology, Medical Imaging, Life Sciences, Biochemistry, Immunology,
Traumatic Brain Injury   Alzheimer's Disease   B Cells   Neuropathology   Neurobehavioral Impairment   Immune Response   5xFAD Mice  

Research Report: Long-Term Effects of Class II Invariant Peptide (CLIP) Antagonism on CLIP+ B Cells in the Meninges, Neuropathology, and Neurobehavioral Deficits in 5xFAD Mice Research Background Traumatic brain injury (TBI) is a significant public health problem affecting millions of individuals worldwide each year. More importantly, TBI is a sign...

Single-Cell RNA Sequencing Reveals the Evolution of the Immune Landscape During Perihematomal Edema Progression After Intracerebral Hemorrhage

Medicine, Rheumatology and Immunology, Neurology, Hematology, Life Sciences, Cell Biology, Biochemistry, Immunology,
intracerebral hemorrhage   single cell RNA sequencing   perihematomal edema   immune cell   osteopontin  

Single-cell RNA Sequencing Reveals Evolution of Immune Landscape in Perihematomal Edema Post Hemorrhagic Stroke Research Background Intracerebral hemorrhage (ICH) is one of the global health threats, renowned for its high disability and mortality rates. Among the secondary brain injuries caused by ICH, the formation of perihematomal edema (PHE) is ...

The Therapeutic Role of Interferon-γ in Experimental Autoimmune Encephalomyelitis is Mediated Through a Tolerogenic Subset of Splenic CD11b+ Myeloid Cells

Medicine, Rheumatology and Immunology, Life Sciences, Immunology,
Interferon-γ   Experimental Autoimmune Encephalomyelitis   Splenic CD11b+ Myeloid Cells   Tolerogenic   Multiple Sclerosis   Regulatory T Cells   Immunotherapy  

The Therapeutic Role of IFN-γ in Experimental Autoimmune Encephalomyelitis is Mediated by Tolerogenic Subsets of Splenic CD11b+ Myeloid Cells Research Background Multiple sclerosis (MS) is a chronic autoimmune disease characterized by demyelination and axonal damage in the central nervous system (CNS). Although the etiology of MS is unclear, both g...

Plasma Proteome-Based Test for First-line Treatment Selection in Metastatic Non–Small Cell Lung Cancer

Medicine, Rheumatology and Immunology, Medical Laboratory Science, Oncology, Life Sciences, Biochemistry, Immunology,
Lung Cancer   Proteomics   Personalized Medicine   Predictive Model   Immunotherapy   Chemotherapy  

In the tumor microenvironment (Tumor Microenvironment, TME), Immune Checkpoint Inhibitors (ICIs) targeting PD-1 or PD-L1 enhance the body’s natural ability to eliminate cancer cells by disrupting the inhibitory receptor-ligand interaction. However, even so, critical trials indicate that the response rate for monotherapy is <50%, with a median Progr...

Inhibition of S6K Lowers Age-Related Inflammation and Increases Lifespan Through the Endolysosomal System

Medicine, Rheumatology and Immunology, Geriatrics, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics, Biophysics,
S6K   inflammation   lifespan   endolysosomal system   autophagy  

Inhibition of S6K Reduces Age-Related Inflammation and Extends Lifespan through the Endosomal-Lysosomal System Research Background and Problem Description As organisms age, chronic low-grade inflammation (inflammaging) and declined immune function (immunosenescence) become important pathological foundations of many diseases in the elderly, such as ...