Differences in the Characteristics and Functions of Brain and Spinal Cord Regulatory T Cells

Medicine, Rheumatology and Immunology, Neurology, Life Sciences, Immunology,
Regulatory T cells   Autoimmune diseases   Brain   Spinal cord   Tissue-specificity   Inflammation suppression   Immune tolerance  

Research Report: Differential Characteristics and Functions of Regulatory T Cells in the Brain and Spinal Cord Research Background and Motivation This study explored the characteristics and functional differences of regulatory T cells (Tregs) within the central nervous system (CNS). Tregs play a key role in the adaptive immune response, primarily b...

Sex-dependent effects of carbohydrate source and quantity on caspase-1 activity in the mouse central nervous system

Medicine, Rheumatology and Immunology, Environmental and Public Health, Neurology, Life Sciences, Cell Biology, Immunology,
high glycemic index diet   ketogenic diet   glucose intolerance   inflammation   inflammasome   neuroinflammation   sex  

The Gender-Dependent Effects of Carbohydrate Sources and Quantity on Caspase-1 Activity in the Central Nervous System of Mice Research Background With the global intensification of aging, the incidence of cognitive impairments and dementia is rapidly increasing, with Alzheimer’s disease being the most common form of senile dementia. Studies have sh...

Therapeutic Potential of 2-Bromo-1,4-Naphthoquinone in Multiple Sclerosis

Medicine, Rheumatology and Immunology, Neurology, Life Sciences, Biochemistry, Immunology,
Multiple Sclerosis   2-Bromo-1,4-Naphthoquinone   Immunomodulation   Central Nervous System   Autoimmune Disease  

2-Bromo-1,4-naphthoquinone Promotes CD8+ T Cell Expansion and Limits Th1/Th17 Cell Development to Alleviate Experimental Autoimmune Encephalomyelitis Introduction Multiple Sclerosis (MS) is a chronic autoimmune disease that primarily affects the Central Nervous System (CNS), impacting approximately 3 million people worldwide. The onset of MS is ass...

CCR5-overexpressing mesenchymal stem cells protect against experimental autoimmune uveitis: insights from single-cell transcriptome analysis

Medicine, Rheumatology and Immunology, Ophthalmology, Life Sciences, Cell Biology, Biochemistry, Immunology,
CCR5   mesenchymal stem cells   autoimmune uveitis   single-cell transcriptome analysis   ocular inflammation   systemic immune response  

Protective effects of CCR5-overexpressing mesenchymal stem cells on experimental autoimmune uveitis Background Introduction Uveitis is an inflammatory eye disease that seriously threatens vision and can lead to complications such as cataracts, glaucoma, vitreous opacities, retinal detachment, and abnormal retinal vasculature. This disease is widesp...

Role of Inflammation in a Rat Model of Radiation Retinopathy

Medicine, Rheumatology and Immunology, Ophthalmology, Life Sciences, Immunology,
radiation retinopathy   microglia   inflammation   macrophages   blood retinal barrier   microangiopathy   hypoxia   retinal pigment epithelium  

Radiation Retinopathy Research Report Radiation Retinopathy (RR) is a common side effect following radiation therapy (such as brachytherapy or proton beam therapy) in ophthalmic tumor treatments. RR presents as delayed and progressive microvascular alterations, ischemia, and macular edema, which may ultimately lead to vision loss, neovascular glauc...

Astrocytic Stress Response Induced by Exposure to Astrocyte-Binding Antibodies in Pediatric Acute Transverse Myelitis Cases

Medicine, Pediatrics, Rheumatology and Immunology, Neurology, Hematology, Life Sciences, Immunology,
Pediatric   Acute Transverse Myelitis   Astrocytes   Antibodies   Neuroinflammation  

B-cell Response in Pediatric Acute Transverse Myelitis Acute transverse myelitis (ATM) is an autoimmune-mediated inflammatory disease of the spinal cord with an incidence of 1.7-2 cases per million children per year. ATM typically presents with limb weakness, sensory loss, and bladder/bowel dysfunction, with symptoms rapidly developing over hours t...