The Role of EEG Microstates in Predicting Oxcarbazepine Treatment Outcomes in Patients with Newly-Diagnosed Focal Epilepsy

The Role of EEG Microstates in Predicting Oxcarbazepine Treatment Outcomes in Patients with Newly-Diagnosed Focal Epilepsy

Information Science, Computer Science, Artificial Intelligence, Medicine, Neurology, Medical Imaging,
EEG microstates   antiseizure medications   oxcarbazepine   machine learning   epilepsy  

The Role of EEG Microstates in Predicting the Therapeutic Outcomes of Oxcarbazepine in Newly Diagnosed Focal Epilepsy Patients Introduction Background Focal epilepsy is the most common type of epilepsy, accounting for about 60% of all epilepsy cases. The selection of antiepileptic drugs (AEDs) varies depending on the type of epilepsy. In the treatm...

Schwann cell derived pleiotrophin stimulates fibroblast proliferation and excessive collagen deposition in plexiform neurofibroma

Medicine, Medical Laboratory Science, Oral Sciences, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Schwann cells   pleiotrophin   fibroblasts   plexiform neurofibroma   collagen deposition   signaling pathway  

This study explores the interactions between Schwann cells and fibroblasts in neurofibromatosis type 1 (NF1) related plexiform neurofibroma (PNF). The background of the research is based on the high incidence of NF1, which affects about 1 in 3000 newborns worldwide and is associated with a series of unique clinical manifestations. PNF is a common p...

Single-cell atlas reveals the immunosuppressive microenvironment and Treg cells landscapes in recurrent glioblastoma

Medicine, Rheumatology and Immunology, Neurology, Neurosurgery, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
glioblastoma   tumor microenvironment   single-cell sequencing   Treg cells   cerebrospinal fluid   immunosuppression   tumor biomarkers  

Single-Cell Atlas Reveals Immunosuppressive Microenvironment and Treg Cell Distribution in Recurrent Glioblastoma Glioblastoma is the most aggressive brain tumor, with a very high recurrence rate and poor prognosis. Although many studies have explored the tumor microenvironment of this disease, the understanding of the immune microenvironment in re...

Adeno-Associated Virus-Mediated Trastuzumab Delivery to the Central Nervous System for Human Epidermal Growth Factor Receptor 2+ Brain Metastasis

Medicine, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
Adeno-Associated Virus   Trastuzumab   Central Nervous System   Brain Metastasis   Gene Therapy   Breast Cancer   HER2  

AAV-Mediated Trastuzumab Delivery to the Central Nervous System for EGFR2-Positive Brain Metastases Introduction In the treatment of breast cancer, tumors that are human epidermal growth factor receptor 2 (HER2) positive exhibit more aggressive characteristics, posing significant challenges for clinical treatment. Since the approval of trastuzumab ...

A Wearable Fluorescence Imaging Device for Intraoperative Identification of Human Brain Tumors

Engineering, Electrical Engineering, Medicine, Neurology, Neurosurgery, Medical Imaging, Life Sciences, Bioengineering,
Intraoperative imaging device   Malignant glioma   Brain tumors   Fluorescence-guided surgery   Wearable device  

Malignant Glioma (MG) Report Malignant Glioma (MG) is the most common type of primary malignant brain tumor. Surgical resection of MG remains the cornerstone of treatment, and the extent of resection is highly correlated with patient survival. However, it is difficult to distinguish tumor tissue from normal tissue during surgery, which greatly limi...

An Explicit Estimated Baseline Model for Robust Estimation of Fluorophores Using Multiple-Wavelength Excitation Fluorescence Spectroscopy

Physics, Optics, Chemistry, Analytical Chemistry, Medicine, Medical Laboratory Science, Neurology, Neurosurgery, Medical Imaging, Oncology, Life Sciences, Bioengineering,
fluorescence spectroscopy   multiple-wavelength excitation   fluorophores   baseline model   non-linear optics   neuro-oncology   glioma  

Research Background Fluorescence spectroscopy is a widely used method for identifying and quantifying fluorescent substances (fluorophores). However, quantifying the fluorophores of interest becomes challenging when the material contains other fluorophores (baseline fluorophores), especially when the emission spectrum of the baseline is not well-de...