A Quantitative Comparison of Electrode Positions for Respiratory Surface EMG

Medicine, Respiratory System, Neurology, Life Sciences, Bioengineering,
respiratory surface EMG   electrode positioning   quantitative comparison   clinical research   standardization  

A Quantitative Comparison Study of Electrode Positions for Respiratory Surface Electromyography Academic Background Respiratory surface electromyography (SEMG) is a non-invasive technique used to record the electrical activity of respiratory muscles. It is widely applied in analyzing respiratory effort, patient-ventilator asynchrony, and respirator...

O-GlcNAcylation Regulates Tyrosine Hydroxylase Serine 40 Phosphorylation and L-Dopa Levels

Medicine, Neurology, Life Sciences, Biochemistry,
O-GlcNAcylation   Tyrosine Hydroxylase   Serine 40 Phosphorylation   L-Dopa   Neurotransmitter  

O-GlcNAcylation Regulates Tyrosine Hydroxylase Serine 40 Phosphorylation and L-DOPA Levels Research Background In the nervous system, dopamine is a key neurotransmitter, and the rate-limiting enzyme in its synthesis pathway is tyrosine hydroxylase (TH). The activity of TH is regulated by various post-translational modifications (PTMs), among which ...

Transmission of Peripheral Blood α-Synuclein Fibrils Exacerbates Synucleinopathy and Neurodegeneration in Parkinson’s Disease by Endothelial LAG3 Endocytosis

Medicine, Neurology, Life Sciences, Cell Biology, Immunology,
α-synuclein fibrils   Parkinson’s disease   LAG3 endocytosis   peripheral blood transmission   neurodegeneration  

Transmission of Peripheral Blood α-Synuclein Fibrils Exacerbates Synucleinopathy and Neurodegeneration in Parkinson’s Disease via Endothelial LAG3 Endocytosis Academic Background Parkinson’s disease (PD) is an age-related neurodegenerative disorder characterized by the abnormal formation and transmission of α-synuclein (α-syn). Recent studies have ...

Ketones in Cellular Physiology: Metabolic, Signaling, and Therapeutic Advances

Medicine, Geriatrics, Endocrinology, Neurology,
ketones   brain-derived neurotrophic factor   cognitive function   insulin resistance   Alzheimer's disease  

Effects of Exogenous β-Hydroxybutyrate on BDNF Signaling, Cognition, and Amyloid Precursor Protein Processing in Humans with Type 2 Diabetes and Insulin-Resistant Rodents Academic Background Patients with type 2 diabetes (T2D) have a significantly increased risk of developing neurodegenerative diseases, such as Alzheimer’s disease (AD), later in li...

Novel Endocytosis Inhibitors Block Entry of HIV-1 Tat into Neural Cells

Chemistry, Medicinal Chemistry, Medicine, Infectious Diseases, Neurology, Life Sciences, Biochemistry, Immunology,
HIV-1 Tat   endocytosis inhibitors   oxidative stress   DNA damage   neural cells  

Novel Endocytosis Inhibitors Block HIV-1 Tat Protein Entry into Neural Cells Academic Background HIV-1 (human immunodeficiency virus type 1) infection not only leads to immune system exhaustion but is also closely associated with HIV-associated neurocognitive disorders (HAND). Although combined antiretroviral therapy (cART) has significantly improv...

Syntaxin 4-enhanced plasma membrane repair is independent of dysferlin in skeletal muscle

Medicine, Neurology, Life Sciences, Cell Biology, Immunology,
plasma membrane repair   skeletal muscle   dysferlin   Syntaxin 4   SNARE complex  

Syntaxin 4-Enhanced Plasma Membrane Repair is Independent of Dysferlin in Skeletal Muscle Background Introduction Plasma membrane repair (PMR) is a crucial process for cells to maintain membrane integrity, preventing cell death, especially in vital organs such as skeletal muscle. Dysferlin, a sarcolemmal calcium-binding protein, has been shown to p...