Wnt/β-catenin Signaling is Critical for the Tumorigenesis of Choroid Plexus Tumors

Medicine, Pediatrics, Neurology, Oncology, Life Sciences,
choroid plexus tumors   Wnt/β-catenin signaling   tumorigenesis   chromosomal instability   3D model   APC gene   GSK3β inhibitor  

The Critical Role of Wnt/β-catenin Signaling in Choroid Plexus Tumorigenesis Background Introduction The choroid plexus (CHP) is a secretory epithelial structure located in the brain ventricles, primarily responsible for the secretion of cerebrospinal fluid (CSF) and the establishment of the blood-CSF barrier. Choroid plexus tumors (CPTs) are rare ...

ENPP1 Induces Blood–Brain Barrier Dysfunction and Promotes Brain Metastasis Formation in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer

Medicine, Neurology, Neurosurgery, Oncology,
blood-brain barrier   brain metastasis   HER2-positive breast cancer   ENPP1   insulin signaling pathway   endothelial cell dysfunction   prognostic biomarker  

The Role of ENPP1 in Brain Metastasis of HER2-Positive Breast Cancer Academic Background Brain metastasis (BM) is a severe neurological complication in patients with HER2-positive breast cancer (HER2+ BC), with an incidence rate as high as 50%. The formation of brain metastasis is closely related to how tumor cells cross the blood-brain barrier (BB...

Meningeal Solitary Fibrous Tumor Cell States Phenocopy Cerebral Vascular Development and Homeostasis

Medicine, Neurology, Neurosurgery, Oncology,
meningeal solitary fibrous tumor   single-cell RNA sequencing   spatial transcriptomics   cell-cell interactions   cerebral vascular development   tumor microenvironment   WHO histological grading  

Single-Cell and Spatial Transcriptomics Study of Meningeal Solitary Fibrous Tumors Academic Background Meningeal Solitary Fibrous Tumors (SFTs) are rare mesenchymal tumors originating from the meninges of the central nervous system (CNS). Although SFTs are histologically similar to other meningeal tumors (such as meningiomas), their unique clinical...

Contemporary Prognostic Signatures and Refined Risk Stratification of Gliomas: An Analysis of 4400 Tumors

Medicine, Neurology, Neurosurgery, Oncology,
glioma   molecular classification   survival rate   risk stratification   genomic diversity   prognostic features   molecular markers  

Molecular Classification and Prognostic Features of Gliomas Background Introduction Glioma is the most common malignant brain tumor in adults, and its classification, risk stratification, and treatment standards have undergone significant changes in recent years. With the introduction of molecular markers, the classification system for gliomas has ...

Multimodal Deep Learning Improves Recurrence Risk Prediction in Pediatric Low-Grade Gliomas

Information Science, Artificial Intelligence, Medicine, Neurology, Medical Imaging, Oncology,
pediatric low-grade gliomas   deep learning   postoperative recurrence prediction   multimodal model   magnetic resonance imaging   risk stratification   survival analysis  

Application of Deep Learning in Postoperative Recurrence Prediction for Pediatric Low-Grade Gliomas Background Pediatric Low-Grade Gliomas (PLGGs) are one of the most common types of brain tumors in children, accounting for 30%-50% of all central nervous system tumors in children. Although the prognosis of PLGGs is relatively favorable, the risk of...

MYC-Dependent Upregulation of the De Novo Serine and Glycine Synthesis Pathway is a Targetable Metabolic Vulnerability in Group 3 Medulloblastoma

Medicine, Neurology, Neurosurgery, Oncology,
medulloblastoma   MYC amplification   metabolic vulnerability   serine synthesis   glycine synthesis   PHGDH inhibition   therapeutic strategy  

Targeting the Serine/Glycine Synthesis Pathway in MYC-Driven Medulloblastoma Background Medulloblastoma is one of the most common malignant brain tumors in children, accounting for a significant proportion of childhood cancer deaths. Based on molecular characteristics, medulloblastoma is classified into four major subgroups: WNT, SHH, Group 3 (MBGr...