Lipid Droplet Accumulation Mediates Macrophage Survival and Treg Recruitment via the CCL20/CCR6 Axis in Human Hepatocellular Carcinoma

Medicine, Rheumatology and Immunology, Hepatobiliary System, Basic Medical Sciences, Oncology, Life Sciences, Biochemistry, Immunology,
lipid droplets   macrophage survival   CCL20   Treg   hepatocellular carcinoma  

Lipid Droplet Accumulation Mediates Macrophage Survival and Treg Recruitment in Human Hepatocellular Carcinoma via the CCL20/CCR6 Axis Background Macrophages are a major component of the tumor microenvironment (TME) and regulate the entire tumor process. In the TME, macrophages exhibit dynamic heterogeneity and plasticity, which affects their role ...

BAG6 restricts pancreatic cancer progression by suppressing the release of IL33-presenting extracellular vesicles and the activation of mast cells

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
pancreatic cancer   extracellular vesicles   BAG6   mast cells   tumor microenvironment  

Research Report on the Mechanism of BAG6 Restricting Pancreatic Cancer Progression Research Background Pancreatic Ductal Adenocarcinoma (PDAC) has an extremely poor prognosis, with a median survival of only 6 months, urgently requiring new treatment methods. In recent years, studies have found that extracellular vesicles (EVs) released by tumor cel...

Exportin 1 governs the immunosuppressive functions of myeloid-derived suppressor cells in tumors through Erk1/2 nuclear export

Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
tumor   myeloid-derived suppressor cells   Exportin 1   MAPK pathway   anti-tumor immunity  

Paper Report Research Background Myeloid-Derived Suppressor Cells (MDSCs) are a major driving force in tumor immune suppression. Understanding their mechanisms can provide new therapeutic targets to improve anti-tumor immunity, as the development and immunosuppressive function of these cells directly affect anti-tumor immune responses. In preclinic...

Distinct Palmitoylation of FoxP3 Regulates the Function of Regulatory T Cells via Palmitoyltransferases

Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Regulatory T Cells   FoxP3   Palmitoylation   Palmitoyltransferases   Immune Regulation  

Unique Foxp3 Palmitoylation Regulates Tregs Function through Palmitoyltransferases Regulatory T cells (Tregs) play a crucial role in maintaining immune homeostasis and preventing excessive immune responses. As important suppressors of immune reactions, Tregs help maintain immune tolerance, thereby preventing autoimmune diseases. However, in the tum...

Genome-Wide Loss of Heterozygosity Predicts Aggressive, Treatment-Refractory Behavior in Pituitary Neuroendocrine Tumors

Medicine, Endocrinology, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
aggressive pituitary tumor   treatment-refractory pituitary tumor   pituitary carcinoma   pituitary neuroendocrine tumor   loss of heterozygosity   biomarker  

Prediction of Invasiveness and Treatment Resistance Behavior of Pituitary Neuroendocrine Tumors Based on Genome-Wide Loss of Heterozygosity Background: Pituitary neuroendocrine tumors (PitNETs) are mostly benign, but a small portion exhibit invasive and treatment-resistant behaviors, continuing to grow or metastasize even after surgery, conventiona...

Clinically Unfavorable Transcriptome Subtypes of Non-WNT/Non-SHH Medulloblastomas are Associated with a Predominance in Proliferating and Progenitor-Like Cell Subpopulations

Medicine, Pediatrics, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry,
medulloblastoma   non-WNT   non-SHH   subgroups   deconvolution   prognosis  

Association of Adverse Transcriptomic Subtypes of Non-WNT/Non-SHH Medulloblastoma with the Dominance of Proliferative and Progenitor-like Subpopulations Research Background Medulloblastoma (MB) is one of the most common malignant tumors of the central nervous system in children. Based on molecular characteristics, the medical community typically cl...