Clinically Unfavorable Transcriptome Subtypes of Non-WNT/Non-SHH Medulloblastomas are Associated with a Predominance in Proliferating and Progenitor-Like Cell Subpopulations

Medicine, Pediatrics, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry,
medulloblastoma   non-WNT   non-SHH   subgroups   deconvolution   prognosis  

Association of Adverse Transcriptomic Subtypes of Non-WNT/Non-SHH Medulloblastoma with the Dominance of Proliferative and Progenitor-like Subpopulations Research Background Medulloblastoma (MB) is one of the most common malignant tumors of the central nervous system in children. Based on molecular characteristics, the medical community typically cl...

Brain vasculature accumulates tau and is spatially related to tau tangle pathology in Alzheimer's disease

Medicine, Medical Laboratory Science, Geriatrics, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry,
Alzheimer's disease   tau protein   neurofibrillary tangles   blood vessels   cerebral vasculature   cerebral amyloid angiopathy  

Study of Tau Protein Accumulation in Brain Vasculature in Alzheimer’s Disease Background Introduction Alzheimer’s disease is characterized by neurodegeneration, with primary pathological features including amyloid plaques and neurofibrillary tangles (NFTs). These tangles are composed of tau protein, and these pathological changes are closely relate...

Predicting cognitive functioning for patients with a high-grade glioma: Evaluating different representations of tumor location in a common space

Information Science, Artificial Intelligence, Medicine, Neurology, Medical Imaging, Oncology,
cognitive functioning   high-grade glioma   individual predictions   lesion location   parcellations   dimensionality reduction  

Academic Background It is widely recognized that the cognitive function of patients with high-grade glioma is affected by the location and volume of the tumor. However, research on how to accurately predict individual patients’ cognitive function for personalized treatment decisions before and after surgery remains limited. Currently, most studies ...

Retrospective Study of Claudin 18 Isoform 2 Prevalence and Prognostic Association in Gastric and Gastroesophageal Junction Adenocarcinoma

Medicine, Oncology, Life Sciences, Biochemistry, Immunology,
gastric cancer   gastroesophageal junction adenocarcinoma   claudin 18   biomarkers   prognosis   immunohistochemistry   therapeutic target  

Research Report on Claudin 18.2 in Gastric Cancer and Gastroesophageal Junction Adenocarcinoma Background Introduction Gastric cancer and gastroesophageal junction (G/GEJ) adenocarcinoma are major global health burdens. It is estimated that in 2020 alone, there were approximately 1.7 million new cases of gastric and esophageal cancers worldwide, wi...

Predictive Impact of Tumor Mutational Burden on Real-World Outcomes of First-Line Immune Checkpoint Inhibition in Metastatic Melanoma

Predictive Impact of Tumor Mutational Burden on Real-World Outcomes of First-Line Immune Checkpoint Inhibition in Metastatic Melanoma

Medicine, Oncology,
tumor mutational burden   immune checkpoint inhibition   metastatic melanoma   real-world study   biomarkers   efficacy prediction   BRAF status  

Study on Real-world Outcomes of First-line Immune Checkpoint Inhibitor Therapy in Metastatic Melanoma Predicted by Tumor Mutational Burden The treatment of metastatic melanoma has significantly benefited from immune checkpoint inhibitors (ICIs) in recent years. However, despite the remarkable improvement in survival rates among melanoma patients, t...

Regorafenib in Patients with Solid Tumors: Results from the TAPUR Study

Chemistry, Medicinal Chemistry, Medicine, Medical Laboratory Science, Oncology, Life Sciences, Immunology,
Regorafenib   BRAF alterations   tumors   antitumor activity   TAPUR study  

The Use of Regorafenib in Patients with BRAF-Mutant Solid Tumors: A Summary of Results from the TAPUR Study Background Introduction The BRAF gene belongs to the cytoplasmic serine/threonine kinase family and regulates cell proliferation and survival by activating the mitogen-activated protein kinase signaling pathway (MAPK). BRAF mutations can lead...