Regorafenib in Patients with Solid Tumors: Results from the TAPUR Study

Chemistry, Medicinal Chemistry, Medicine, Medical Laboratory Science, Oncology, Life Sciences, Immunology,
Regorafenib   BRAF alterations   tumors   antitumor activity   TAPUR study  

The Use of Regorafenib in Patients with BRAF-Mutant Solid Tumors: A Summary of Results from the TAPUR Study Background Introduction The BRAF gene belongs to the cytoplasmic serine/threonine kinase family and regulates cell proliferation and survival by activating the mitogen-activated protein kinase signaling pathway (MAPK). BRAF mutations can lead...

Tumor Size Is Not Everything: Advancing Radiomics as a Precision Medicine Biomarker in Oncology Drug Development and Clinical Care

Information Science, Computer Science, Artificial Intelligence, Medicine, Medical Laboratory Science, Medical Imaging, Oncology, Life Sciences, Cell Biology, Immunology,
tumor size   precision medicine   radiomics   oncology   drug development   clinical care   multidisciplinary workshop  

In contemporary clinical oncology practice and drug development, the methods for evaluating tumor response are on the cusp of a revolution. Since the World Health Organization (WHO) proposed tumor response classification criteria for assessing the effectiveness of anti-cancer drugs in 1981, this field has undergone several improvements. Notably, th...

Transcriptomic Profiling of Primary Prostate Cancers and Nonlocalized Disease on Prostate-Specific Membrane Antigen PET/CT: A Multicenter Retrospective Study

Medicine, Medical Laboratory Science, Urology, Oncology,
Prostate Cancer   Transcriptomics   Prostate-Specific Membrane Antigen   PET/CT   Genomic Classifier   Multicenter   Retrospective Study  

Transcriptomic Analysis of Prostate Cancer Patients: A Study on Nonlocalized Disease Based on Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography Academic Background Prostate cancer is a common male malignancy, and its diagnosis and treatment are crucial to patient prognosis. Transcriptomic analysis is a technique us...

Phase II Study of Erdafitinib in Tumors with FGFR Mutations or Fusions

Medicine, Basic Medical Sciences, Oncology,
Erdafitinib   FGFR mutations   Tumor fusions   Phase II study   Oncology  

Study on the Efficacy of Erdafitinib in Patients with Tumors with FGFR Mutations or Fusions This academic report is based on the scientific paper “Phase II Study of Erdafitinib in Patients with Tumors with Fibroblast Growth Factor Receptor Mutations or Fusions: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol K2,” and introduces the...

Synthetic Lethality Beyond BRCA: A Phase I Study of Rucaparib and Irinotecan in Metastatic Solid Tumors with Homologous Recombination-Deficiency Mutations

Medicine, Basic Medical Sciences, Pharmacy, Oncology,
Rucaparib   Irinotecan   Metastatic solid tumors   Homologous recombination deficiency   Phase I trial  

Research Background In recent years, Poly ADP-ribose Polymerase (PARP) inhibitors have shown significant efficacy as a key approach to treat hereditary BRCA1/2 mutation cancers. However, their effectiveness on tumors with other homologous recombination deficiency (HRD) gene mutations such as ATM, CDK12, and CHEK2 has been less satisfactory. Hence, ...

Phase II Study of Erdafitinib in Patients with Tumors with FGFR Amplifications: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol K1

Phase II Study of Erdafitinib in Patients with Tumors with FGFR Amplifications: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol K1

Medicine, Oncology, Life Sciences, Biochemistry,
FGFR amplification   Erdafitinib   antitumor efficacy   NCI-MATCH trial   Phase II study  

Phase II Study of Erdafitinib in Patients with FGFR Amplifications: A Detailed Report Background Dysregulation of Fibroblast Growth Factor Receptor (FGFR) family signaling pathways is widely recognized to be associated with cancer development, progression, and treatment resistance. This study primarily investigates tumors with FGFR1-4 amplification...