Impact of PD1 Blockade Added to Neoadjuvant Chemoradiotherapy on Rectal Cancer Surgery: Post-Hoc Analysis of the Randomized POLARSTAR Trial

Background Colorectal cancer is the third most common cancer type globally, with the greatest disease burden in East Asia. In China, 47% of newly diagnosed colorectal cancers are rectal cancers, of which 70% are radiologically staged as locally advanced (stage II/III) at diagnosis. For decades, neoadjuvant chemoradiotherapy (CRT) combined with tota...

Impact of Postoperative Complications on Clinical Outcomes After Gastrectomy for Cancer: Multicentre Study

Gastric cancer is one of the most common malignant tumors worldwide, and surgical resection (gastrectomy) is the primary treatment. Although the application of minimally invasive techniques has reduced surgical trauma, the incidence of postoperative complications after gastrectomy remains high, ranging from 20% to 40%. These complications not only ...

Development and External Validation of Prediction Risk Scores (StrISK and NOFA) to Predict Immediate Surgical Need in Adhesive Small Bowel Obstruction: An Observational Prospective Multicentre Study

Background Introduction Adhesive Small Bowel Obstruction (ASBO) is one of the leading causes of emergency admissions, accounting for approximately 60% of all small bowel obstruction cases. ASBO is often caused by postoperative intra-abdominal adhesions, with patients presenting symptoms such as abdominal pain, vomiting, and constipation. While most...

Routine Anaesthesia Ward-Based Patient Visits in Surgery: 1-Year Outcomes of the TRACE Randomized Clinical Trial

In perioperative medicine, the long-term clinical and functional recovery of postoperative patients has always been a focus of research. Traditionally, postoperative complications, mortality, readmission rates, and reoperation rates have been the primary indicators for measuring surgical patient outcomes. However, as medical research deepens, an in...

Parathyroid Vascular Anatomy Using Intraoperative Mapping Angiography: The Paratlas Study

Academic Background The preservation of the parathyroid glands (PGs) during thyroidectomy is crucial, as postoperative hypoparathyroidism is a common complication of thyroid surgery, particularly after total thyroidectomy. Approximately 30%-40% of patients experience transient hypoparathyroidism, with 5%-10% developing permanent hypoparathyroidism....

Preoperative Stereotactic Radiotherapy to Prevent Pancreatic Fistula in High-Risk Patients Undergoing Pancreatoduodenectomy (FIBROPANC): Prospective Multicentre Phase II Single-Arm Trial

Pancreaticoduodenectomy is a common surgery for treating tumors of the pancreas and surrounding organs, but postoperative pancreatic fistula (POPF) is one of its major complications, especially in high-risk patients, where the incidence of POPF can be as high as 50%. POPF not only increases hospitalization time and medical costs but can also lead t...

Detecting Residual Disease After Neoadjuvant Chemoradiotherapy for Oesophageal Squamous Cell Carcinoma: Prospective Multicentre PRESINO Trial

Oesophageal Squamous Cell Carcinoma (OSCC) is one of the most common malignant tumours globally, with a particularly high incidence in East Asia. Neoadjuvant Chemoradiotherapy (NCRT) is the standard treatment for locally advanced oesophageal cancer, aiming to reduce tumour volume and improve surgical resection rates. However, some patients may achi...

Carbohydrate Antigen 19-9 (CA19-9) Response After Induction FOLFIRINOX for Locally Advanced Pancreatic Cancer Identifies Patients Who May Benefit from Surgical Exploration: Multicentre, Observational Cohort Study

Pancreatic cancer is a highly malignant tumor with an extremely low five-year survival rate, especially for patients with locally advanced pancreatic cancer (LAPC), who have limited treatment options and poor prognosis. LAPC is defined based on the degree of tumor contact with adjacent blood vessels and is often considered “unresectable” at diagnos...

Patient-Reported Outcomes 3 and 18 Months After Mastectomy and Immediate Prepectoral Implant-Based Breast Reconstruction in the UK PRE-BRA Prospective Multicentre Cohort Study

Mastectomy is a common surgical procedure in the treatment of breast cancer, with approximately 55,000 women diagnosed with breast cancer each year in the UK, of whom up to 40% undergo mastectomy. Mastectomy has a profound impact on women’s physical and mental health, and the UK National Institute for Health and Care Excellence (NICE) recommends th...

Tumour Deposit Count is an Independent Prognostic Factor in Colorectal Cancer—A Population-Based Cohort Study

Colorectal Cancer (CRC) is the third most common malignant tumor worldwide, and its prognosis assessment primarily relies on the TNM staging system. However, the current TNM staging system does not fully account for the presence and count of Tumor Deposits (TDs) in lymph node-positive colorectal cancer. Tumor deposits refer to discrete tumor nodule...