Association Study of Polymorphic Single-Nucleotide Variants in miRNA Genes and Colorectal Cancer Susceptibility Academic Background Colorectal cancer (CRC) is one of the most common malignancies with high incidence and mortality rates worldwide. According to global cancer statistics in 2022, CRC ranks as the third most prevalent cancer, with over 1...

Exploring Cervical Adenocarcinoma: Epidemiology, Diagnostic and Therapeutic Challenges, and Pathogenetic Mechanisms Academic Background Cervical cancer poses a significant threat to women’s health globally, particularly in developing countries. The main histological types of cervical cancer include squamous cell carcinoma (SCC) and cervical adenoca...

The Application of Proton Magnetic Resonance Spectroscopy in Fetal and Neonatal Brain Research Background Introduction The brain undergoes rapid biochemical and structural changes during fetal and neonatal development. These changes are crucial for understanding normal development and the mechanisms underlying neurological disorders. However, tradi...

Prognostic Prediction Model for Esophageal Squamous Cell Carcinoma Based on Single-Cell RNA Sequencing and Bulk RNA Sequencing Research Background Esophageal Squamous Cell Carcinoma (ESCC) is one of the most common malignant tumors globally, particularly prevalent in East Asia. Despite existing treatment methods such as surgery, endoscopic resectio...

Reliability of Central Vein Sign Imaging with 3T FLAIR* in a Multicenter Study Academic Background Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by the formation of white matter lesions (WMLs). Magnetic Resonance Imaging (MRI) is a crucial tool for diagnosing and monitoring MS, particularly T2...

Evaluation of Treatment Outcomes Using DNLR and GNRI in Combination Therapy for Hepatocellular Carcinoma Background Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide, particularly in Asia. Due to its lack of early symptoms, many patients are diagnosed at an advanced stage, making surgical resection unfeasible. In r...

Application of High Dielectric Constant Pads in 3T Fetal MRI Background Introduction With the advancement of medical imaging technology, fetal MRI (Magnetic Resonance Imaging) is increasingly being used in prenatal diagnosis. Compared to ultrasound, MRI provides higher soft tissue resolution and contrast, offering significant advantages in imaging ...

Larger Perfusion Mismatch Volume is Associated with Longer Hospital Length of Stay in Medium Vessel Occlusion Stroke Academic Background Stroke is the second leading cause of death globally, imposing a significant burden on both patients and healthcare systems. Prolonged hospital length of stay (LOS) is closely associated with adverse clinical outc...

The Impact of Winter Urban Light on Night-Time Sleep Background Light and darkness are the primary environmental factors regulating human circadian rhythms. In natural environments, humans are exposed to light levels ranging from 3,000 lux (cloudy winter sky) to 100,000 lux (clear sky). However, in modern urban environments, especially during winte...

Causal Relationship Between Gut Microbiota and Parkinson’s Disease Academic Background Parkinson’s Disease (PD) is a common neurodegenerative disorder characterized by motor dysfunction (such as bradykinesia, muscle rigidity, and resting tremors) and non-motor symptoms (such as olfactory impairment, cognitive decline, and sleep disturbances). Altho...