Clinical Analysis of MOG Antibody-Associated Disease Overlapping with Anti-NMDAR Encephalitis Background In recent years, with the in-depth study of autoimmune encephalitis (AE) and demyelinating diseases of the central nervous system (CNS), scientists have identified some rare cases of overlapping syndromes. Among them, the overlap between MOG Ant...

Periodic and Aperiodic Components of Subthalamic Nucleus Activity Reflect Different Aspects of Motor Impairment in Parkinson’s Disease Background Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by core symptoms such as bradykinesia, rigidity, and tremor. Although the neurophysiology of PD has been extensively studied, ...

Oscillatory Transcranial Electrical Stimulation and the Quantitative Features of Phosphene Perception Background Introduction Phosphenes refer to the phenomenon of perceiving light points without any external visual stimuli. This phenomenon holds significant importance in visual neuroscience and consciousness studies, as it helps us understand how ...

Functional Connectivity of the Default Mode Network During Opioid Use and Cessation Background Opioid abuse has become a global public health issue, particularly in the United States, where opioid overdose deaths have tripled since 1999. Opioids not only lead to addiction but are also associated with chronic pain, immune system suppression, and neu...

The Role of Oxyglutamate Carrier in Cerebral Ischemia-Reperfusion Injury Academic Background Cerebral ischemia-reperfusion injury (I/R) is a significant issue in the treatment of ischemic stroke. Although rapid blood flow restoration through thrombectomy and intravenous rt-PA (recombinant tissue plasminogen activator) administration can effectively...

Metabolic Characteristics of Pancreatic Ductal Adenocarcinoma (PDAC) Subtypes Background Pancreatic Ductal Adenocarcinoma (PDAC) is a highly aggressive cancer with a five-year survival rate of only 13%, making it the third leading cause of cancer-related deaths. The aggressiveness and chemoresistance of PDAC are closely linked to its complex metabo...

Metabolism of High-Grade Serous Ovarian Carcinoma (HGSOC) Cells Academic Background High-Grade Serous Ovarian Carcinoma (HGSOC) is the most common and aggressive subtype of epithelial ovarian cancer. Most patients are diagnosed at stage III or IV, with a 5-year survival rate ranging from 20% to 40%. Treatment for HGSOC typically involves surgical r...

PAF1/HIF1α Axis Promotes Pancreatic Cancer Aggressiveness by Regulating Glycolytic Metabolism Background Pancreatic cancer (PC) is a highly aggressive malignant tumor, with pancreatic ductal adenocarcinoma (PDAC) being the most common type. Despite significant advancements in cancer treatment in recent years, the 5-year survival rate for pancreatic...

The Role and Mechanism of STEAP3 in Cervical Cancer Background Cervical cancer (CC) is the fourth most common cancer among women globally, with approximately 600,000 new cases and 300,000 deaths annually. Although the five-year survival rate for early-stage cervical cancer patients exceeds 85% through treatments such as surgery, radiotherapy, and c...

Phosphatidylinositol Promotes Pituitary Adenoma Cell Proliferation and Invasion by Regulating POU1F1 Expression Background Pituitary adenoma (PA) is one of the most common primary intracranial tumors, accounting for approximately 15% of all intracranial tumors. Although most pituitary adenomas are benign, about 30% of them are invasive, known as in...