Isorhamnetin Ameliorates Dopaminergic Neuronal Damage via Targeting FOSL1 to Activate AKT/mTOR in 6-OHDA-Induced SH-SY5Y Cells

Medicine, Neurology, Life Sciences,
Isorhamnetin   FOSL1   AKT/mTOR pathway   6-OHDA   Parkinson's disease   oxidative stress   apoptosis  

Isorhamnetin Ameliorates 6-OHDA-Induced SH-SY5Y Cell Damage by Targeting FosL1 to Activate the Akt/mTOR Pathway Academic Background Parkinson’s Disease (PD) is a chronic neurodegenerative disorder characterized by the loss of dopaminergic neurons in the Substantia Nigra Pars Compacta (SNpc). This neuronal loss is closely associated with mitochondri...

The Role of Cognitive Load on Interlimb Differences in Motor Coordination in Older Adults

Medicine, Geriatrics, Neurology,
cognitive load   motor coordination   interlimb differences   older adults   reaction time   joint cocontraction   motor control  

The Impact of Cognitive Load on Interlimb Differences in Motor Control in Older Adults Academic Background In daily life, we often observe that the dominant hand (e.g., the right hand in right-handed individuals) performs better than the non-dominant hand in simple tasks. However, these interlimb differences may be influenced by task complexity and...

Neuroimaging Meets Neurophysiology: Are There Cortical Somatotopic Motor Maps Outside of the Human Precentral Gyrus?

Medicine, Psychiatry, Neurology, Clinical Psychology, Medical Imaging,
somatotopic motor maps   lateral occipitotemporal cortex   precuneus   functional MRI   motor control  

New Discoveries in Cortical Motor Maps Background Introduction Humans and other primates are capable of performing a wide range of complex body movements, the initiation and control of which rely on multiple cortical and subcortical structures. Among these, the primary motor cortex (M1), located in the precentral gyrus, is the core region for execu...

The Mevalonate Pathway Contributes to Breast Primary Tumorigenesis and Lung Metastasis

Medicine, Oncology,
mevalonate pathway   breast cancer   lung metastasis   Rho GTPases   cholesterol   gene expression   tumor recurrence  

Regulation of the Mevalonate Pathway in Breast Cancer and Its Role in Tumorigenesis and Lung Metastasis Background Introduction Breast cancer is one of the most common cancers among women worldwide, and its occurrence and metastasis mechanisms are complex, involving abnormal regulation of multiple signaling pathways and metabolic processes. In rece...

Platelet-Activating Factor: A Potential Therapeutic Target to Improve Cancer Immunotherapy

Medicine, Oncology, Life Sciences, Immunology,
tumor microenvironment   immunosuppression   platelet-activating factor   neutrophils   cancer immunotherapy  

The Potential Role of Platelet-Activating Factor in Cancer Immunotherapy Background Cancer immunotherapy has been a significant breakthrough in cancer treatment in recent years, but its efficacy is still limited by the immunosuppressive mechanisms within the tumor microenvironment (TME). The TME supports the differentiation and proliferation of mye...

Patient-Derived Acellular Ascites Fluid Affects Drug Responses in Ovarian Cancer Cell Lines Through the Activation of Key Signalling Pathways

Medicine, Obstetrics and Gynecology, Oncology, Life Sciences, Immunology,
ovarian cancer   acellular ascites fluid   drug sensitivity   signalling pathways   chemoresistance  

Impact of Patient-Derived Acellular Ascites on Drug Responses in Ovarian Cancer Cell Lines Through Activation of Key Signaling Pathways Background Ovarian cancer is one of the deadliest gynecological malignancies, with a 5-year survival rate of only 30% for patients with advanced epithelial ovarian cancer (EOC). Although surgery and chemotherapy (e...