Cerebrospinal Fluid Dynamics and Subarachnoid Space Occlusion Following Traumatic Spinal Cord Injury in the Pig: An Investigation Using Magnetic Resonance Imaging

Medicine, Neurology, Medical Imaging,
Traumatic Spinal Cord Injury   Cerebrospinal Fluid Dynamics   Subarachnoid Space Occlusion   Magnetic Resonance Imaging   Pig Model   Acute Clinical Management   Spinal Cord Swelling  

Study on Cerebrospinal Fluid Dynamics Following Traumatic Spinal Cord Injury in a Porcine Model Background Traumatic Spinal Cord Injury (SCI) is a severe neurological disorder that often leads to permanent neurological dysfunction. Despite years of efforts by scientists to develop treatments, progress has been limited due to the complex pathophysio...

Plasma S100β as a Predictor for Pathology and Cognitive Decline in Alzheimer’s Disease

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Biochemistry,
blood-brain barrier   Alzheimer’s disease   S100β   cognitive decline   biomarker  

Plasma S100β as a Predictor for Pathology and Cognitive Decline in Alzheimer’s Disease Academic Background Alzheimer’s Disease (AD) is the most common form of dementia, characterized by the deposition of β-amyloid (Aβ) plaques and the aggregation of hyperphosphorylated microtubule-associated protein tau (tau). These pathological changes lead to gra...

Venous Compression Causes Chronic Cerebral Ischaemia in Normal Pressure Hydrocephalus Patients

Medicine, Neurology,
Normal Pressure Hydrocephalus   Chronic Cerebral Ischaemia   Venous Compression   Cerebral Blood Flow Regulation   Intracranial Pressure  

Chronic Cerebral Ischemia and Its Association with Normal Pressure Hydrocephalus Academic Background Normal Pressure Hydrocephalus (NPH) is a potentially reversible dementia characterized by cognitive impairment, gait disturbance, and urinary incontinence. Despite only a mild increase in intracranial pressure (ICP, approximately 15 mmHg), patients ...

Breaking Boundaries: Role of the Brain Barriers in Metastatic Process

Medicine, Neurology, Oncology,
brain metastasis   blood-brain barrier   blood-spinal cord barrier   blood-cerebrospinal fluid barrier   cancer   metastatic mechanisms   therapeutic challenges  

The Role of Brain Barriers in Brain Metastasis Background Introduction Brain metastases (BMs) are the most common intracranial tumors in adults, occurring 3 to 10 times more frequently than primary brain tumors. Despite multimodal treatments including surgical resection, radiotherapy, and chemotherapy, the prognosis for brain metastases remains poo...

Transmantle Pressure Under the Influence of Free Breathing: Non-Invasive Quantification of the Aqueduct Pressure Gradient in Healthy Adults

Medicine, Neurology, Medical Imaging,
cerebrospinal fluid circulation   transmantle pressure   aqueduct resistance   free breathing   real-time phase contrast MRI   neurodegenerative diseases   non-invasive quantification  

Non-invasive Quantification of Cerebrospinal Fluid Dynamics and Ventricle-Subarachnoid Space Pressure Gradient Background Cerebrospinal fluid (CSF) is a vital component of the central nervous system, providing protection to brain tissue, maintaining intracranial pressure stability, and facilitating the clearance of metabolic waste. Abnormal CSF cir...

Research Priorities for Improving Cognitive and Neuropsychological Outcomes in Hydrocephalus

Medicine, Psychiatry, Neurology, Neurosurgery, Clinical Psychology,
hydrocephalus   neuropsychology   cognition   research priorities   quality of life   clinical assessment   animal models  

Research Priorities for Improving Cognitive and Neuropsychological Outcomes in Hydrocephalus Academic Background Hydrocephalus is a neurological disorder affecting approximately 85 per 100,000 individuals worldwide. It is closely associated with motor and cognitive impairments. Although advancements in surgical interventions have significantly impr...