Microglia and Macrophages in Glioblastoma: Landscapes and Treatment Directions

Medicine, Neurology, Neurosurgery, Oncology, Life Sciences, Immunology,
glioblastoma   microglia   macrophages   tumor microenvironment   immunotherapy   single-cell sequencing   tumor-associated macrophages  

Microglia and Macrophages in Glioblastoma Academic Background Glioblastoma (GBM) is the most common primary malignant tumor of the central nervous system, characterized by high invasiveness and lethality. Despite standard treatments such as surgery, chemotherapy, and radiotherapy, the survival rate of patients remains extremely limited, with a medi...

From Bedside to Bench: New Insights in Epilepsy-Associated Tumors Based on Recent Classification Updates and Animal Models on Brain Tumor Networks

Medicine, Neurology, Neurosurgery, Medical Imaging, Oncology,
low-grade neuroepithelial tumors   epilepsy   in utero electroporation   mouse model   neuronal activity   brain tumors   neuro-oncology  

Latest Research on Epilepsy-Associated Tumors: Classification and Animal Models Background Epilepsy is a common neurological disorder, and some patients are accompanied by brain tumors, particularly low-grade neuroepithelial tumors (LGNTs). These tumors typically grow slowly but are highly associated with drug-resistant epilepsy. Although research ...

The Multifaceted Therapeutical Role of Low-Density Lipoprotein Receptor Family in High-Grade Glioma

Medicine, Neurology, Neurosurgery, Oncology,
Low-Density Lipoprotein Receptor   High-Grade Glioma   Targeted Therapies   Tumorigenesis   Signaling Pathways  

The Multifaceted Therapeutic Role of the Low-Density Lipoprotein Receptor Family in High-Grade Glioma Academic Background High-grade gliomas (HGG) are the most aggressive and prevalent primary brain tumors in the central nervous system (CNS), accounting for approximately 80% of all malignant brain tumors. Among them, glioblastoma (GBM) is the most ...

In Vivo Brain Delivery of BBB-Enabled Iduronate 2-Sulfatase in Rats

Medicine, Neurology, Life Sciences, Biochemistry,
blood brain barrier   MPS II   iduronate-2-sulfatase   enzyme replacement therapy   CSF   brain   pharmacokinetics  

Delivery of Enzyme Replacement Therapy Across the Blood-Brain Barrier for Hunter Syndrome Background Hunter syndrome (Mucopolysaccharidosis II, MPS II) is a rare inherited metabolic disorder caused by a deficiency of the iduronate-2-sulfatase (IDS) enzyme. This enzyme deficiency leads to the accumulation of glycosaminoglycans (such as heparan sulfa...

Relaxin-2 Attenuates Oxidative Stress and Neuronal Apoptosis via the ERK-nNOS-NO Pathway After Germinal Matrix Hemorrhage in Rats

Medicine, Neurology, Neurosurgery,
oxidative stress   neuronal apoptosis   relaxin-2   ERK-nNOS-NO pathway   germinal matrix hemorrhage   rat model   neuroprotection  

rh-relaxin-2 Attenuates Oxidative Stress and Neuronal Apoptosis via the ERK-nNOS-NO Pathway After Germinal Matrix Hemorrhage in Rats Academic Background Germinal Matrix Hemorrhage (GMH) is one of the most common neurological disorders in newborns, particularly in preterm infants, and is a major cause of brain injury. GMH not only triggers acute inf...

Cerebrospinal Fluid Dynamics and Subarachnoid Space Occlusion Following Traumatic Spinal Cord Injury in the Pig: An Investigation Using Magnetic Resonance Imaging

Medicine, Neurology, Medical Imaging,
Traumatic Spinal Cord Injury   Cerebrospinal Fluid Dynamics   Subarachnoid Space Occlusion   Magnetic Resonance Imaging   Pig Model   Acute Clinical Management   Spinal Cord Swelling  

Study on Cerebrospinal Fluid Dynamics Following Traumatic Spinal Cord Injury in a Porcine Model Background Traumatic Spinal Cord Injury (SCI) is a severe neurological disorder that often leads to permanent neurological dysfunction. Despite years of efforts by scientists to develop treatments, progress has been limited due to the complex pathophysio...