Chemical Activation of Mitochondrial CLPP to Modulate Energy Metabolism of CD4+ T Cell for Inflammatory Bowel Diseases Treatment

Medicine, Rheumatology and Immunology, Gastroenterology, Life Sciences, Immunology,
Inflammatory Bowel Disease   Mitochondrial CLPP   CD4+ T Cells   Oxidative Phosphorylation   Th17/Treg Balance  

Academic Background Inflammatory Bowel Disease (IBD) is a chronic, relapsing autoimmune disorder primarily comprising Crohn’s Disease (CD) and Ulcerative Colitis (UC). The exact pathogenesis of IBD remains unclear, but it is known that abnormal immune responses play a critical role in its development, particularly the imbalance of CD4+ T cells. The...

Structure-Guided Development of Selective Caseinolytic Protease P Agonists as Antistaphylococcal Agents

Chemistry, Medicinal Chemistry, Medicine, Infectious Diseases, Pharmacy, Life Sciences, Biochemistry, Microbiology,
Caseinolytic Protease P   Antistaphylococcal Agents   ZG297   MRSA   Structure-Guided Design   Selective Agonists   Antibiotics  

Structure-Guided Development of Selective Caseinolytic Protease P Agonists as Antistaphylococcal Agents Academic Background Staphylococcus aureus is a common Gram-positive pathogen that can cause various human infections, including skin and soft tissue infections. With the widespread dissemination of methicillin-resistant Staphylococcus aureus (MRS...

A Prognostic Molecular Signature of Hepatic Steatosis is Spatially Heterogeneous and Dynamic in Human Liver

Medicine, Hepatobiliary System, Endocrinology, Gastroenterology,
hepatic steatosis   molecular signature   spatial heterogeneity   dynamic   liver   metabolic disease   biomarkers  

Academic Background Metabolic-associated Steatotic Liver Disease (MASLD) is a major health issue affecting over 30% of the global population and is closely related to various chronic diseases such as cancer, cardiovascular disease, and renal dysfunction. The pathological spectrum of MASLD ranges from simple steatosis to steatohepatitis and progress...

Foundation Model of ECG Diagnosis: Diagnostics and Explanations

Information Science, Artificial Intelligence, Medicine, Cardiovascular System,
ECG   diagnostic model   zero-shot diagnosis   knowledge enhancement   multi-center data  

Research on ECG Diagnosis Foundation Model Based on Signal-Language Architecture Academic Background Cardiovascular disease (CVD) is the leading cause of death worldwide, and early identification of high-risk populations is crucial. The electrocardiogram (ECG), a non-invasive, cost-effective, and widely used diagnostic tool, is recorded over 300 mi...

The Neonatal Gut Microbiota: A Role in the Encephalopathy of Prematurity

The Neonatal Gut Microbiota: A Role in the Encephalopathy of Prematurity

Medicine, Pediatrics, Neurology, Life Sciences, Biochemistry, Microbiology,
preterm infants   gut microbiota   encephalopathy   neurodevelopment   metabolic pathways  

The Role of the Neonatal Gut Microbiota in the Encephalopathy of Prematurity: A Comprehensive Study Academic Background Premature birth (defined as birth before 37 weeks of gestation) is a common issue globally, affecting approximately 10% of pregnancies. Preterm infants are at risk of abnormal brain development, known as Encephalopathy of Prematur...

A Glucocorticoid Spike Derails Muscle Repair to Heterotopic Ossification After Spinal Cord Injury

A Glucocorticoid Spike Derails Muscle Repair to Heterotopic Ossification After Spinal Cord Injury

Medicine, Basic Medical Sciences, Neurology, Life Sciences,
glucocorticoid   heterotopic ossification   spinal cord injury   muscle repair   receptor antagonist  

Academic Background and Problem Statement Neurogenic Heterotopic Ossification (NHO) is a pathological condition where ectopic bone tissue forms in muscles following severe central nervous system (CNS) injuries, such as spinal cord injury (SCI), traumatic brain injury (TBI), or stroke. NHO not only impairs motor function but can also lead to joint s...