Neutralizing GDF-15 Can Overcome Anti-PD-1 and Anti-PD-L1 Resistance in Solid Tumours

Medicine, Oncology, Life Sciences, Immunology,
GDF-15   anti-PD-1   anti-PD-L1   solid tumours   immune checkpoint inhibitors   drug resistance   clinical trial  

Academic Background and Problem Statement In recent years, immune checkpoint inhibitors (ICIs) have made significant progress in cancer treatment, particularly anti-PD-1 and anti-PD-L1 antibodies, which have become the standard of care for first-line treatment in various cancers. However, despite the notable clinical activity of these therapies in ...

Synaptic Basis of Feature Selectivity in Hippocampal Neurons

Medicine, Neurology, Life Sciences, Biophysics,
synaptic plasticity   hippocampal neurons   spatial selectivity   memory encoding   optical approach  

Synaptic Basis of Feature Selectivity in Hippocampal Neurons Academic Background A central question in neuroscience is how synaptic plasticity shapes the feature selectivity of neurons in behaving animals. Hippocampal CA1 pyramidal neurons (CA1PNs) exhibit one of the most striking forms of feature selectivity by forming spatially and contextually s...

Native DGC Structure Rationalizes Muscular Dystrophy-Causing Mutations

Medicine, Neurology, Life Sciences, Biochemistry, Immunology, Genetics,
Duchenne Muscular Dystrophy   Muscular Dystrophy   Dystrophy-Causing Mutations   Muscular Dystrophy Treatment   Muscular Dystrophy Gene  

Academic Background Duchenne Muscular Dystrophy (DMD) is a severe X-linked recessive disorder characterized by progressive muscle wasting, leading to premature mortality. The cause of DMD is mutations in the gene encoding dystrophin, a protein that, along with other proteins at the muscle cell membrane, forms the Dystrophin-Glycoprotein Complex (DG...

Long-Term Clinical and Safety Outcomes from a Single-Site Phase 1 Study of Neural Stem Cell Transplantation for Chronic Thoracic Spinal Cord Injury

Medicine, Neurology, Neurosurgery,
neural stem cell transplantation   chronic thoracic spinal cord injury   long-term safety   clinical study   neurological improvement  

Long-term Clinical and Safety Outcomes from a Single-site Phase 1 Study of Neural Stem Cell Transplantation for Chronic Thoracic Spinal Cord Injury Academic Background Spinal cord injury (SCI) is a severe neurological condition that causes significant disability in millions of people worldwide. Traditional treatments primarily focus on stabilizing ...

The Respiratory Microbiome is Linked to the Severity of RSV Infections and the Persistence of Symptoms in Children

Medicine, Infectious Diseases, Pediatrics, Respiratory System, Life Sciences, Microbiology,
respiratory microbiome   RSV infection   symptom persistence   child health   microbial community  

The Respiratory Microbiome is Linked to the Severity of RSV Infections and the Persistence of Symptoms in Children Academic Background Respiratory Syncytial Virus (RSV) is a leading cause of respiratory infections and hospitalizations in infants. While known risk factors for severe infections include preterm birth, congenital heart disease, and bro...

Ongoing Evolution of SARS-CoV-2 Drives Escape from mRNA Vaccine-Induced Humoral Immunity

Medicine, Infectious Diseases, Life Sciences, Immunology, Microbiology,
SARS-CoV-2   mRNA vaccine   humoral immunity   viral mutation   neutralizing antibodies  

The Ongoing Evolution of SARS-CoV-2 Drives Escape from mRNA Vaccine-Induced Humoral Immunity Academic Background Since its emergence in late 2019, SARS-CoV-2 has undergone continuous evolution, giving rise to multiple variants. These variants have enhanced their transmissibility and immune evasion capabilities through mutations, particularly agains...