A Glucocorticoid Spike Derails Muscle Repair to Heterotopic Ossification After Spinal Cord Injury

A Glucocorticoid Spike Derails Muscle Repair to Heterotopic Ossification After Spinal Cord Injury

Academic Background and Problem Statement Neurogenic Heterotopic Ossification (NHO) is a pathological condition where ectopic bone tissue forms in muscles following severe central nervous system (CNS) injuries, such as spinal cord injury (SCI), traumatic brain injury (TBI), or stroke. NHO not only impairs motor function but can also lead to joint s...

Cycling Alpha Cells in Regenerative Drug-Treated Human Pancreatic Islets May Serve as Key Beta Cell Progenitors

Academic Background Diabetes is a global health issue affecting over 500 million people. Both type 1 diabetes (T1D) and type 2 diabetes (T2D) share the common feature of a significant reduction in the number of functional insulin-secreting beta cells. Therefore, restoring or increasing beta cell mass is considered a key strategy in diabetes treatme...

Toward Optimal Disease Surveillance with Graph-Based Active Learning

Toward Optimal Disease Surveillance with Graph-Based Active Learning Academic Background With the acceleration of globalization, the speed and scope of infectious disease transmission have significantly increased. How to effectively monitor and control the spread of infectious diseases has become a critical issue in public health. Traditional disea...

Engineering Bacteria for Cancer Immunotherapy by Inhibiting IDO Activity and Reprogramming CD8+ T Cell Response

Synthetic Biology in Cancer Immunotherapy: Engineering Bacteria to Inhibit IDO Activity and Reprogram CD8+ T Cell Responses Academic Background In recent years, significant progress has been made in cancer immunotherapy, particularly through the activation of T cells to combat tumors. However, metabolic adaptations in the tumor microenvironment (TM...

Cyanobacteria–Probiotics Symbionts for Modulation of Intestinal Inflammation and Microbiome Dysregulation in Colitis

Cyanobacteria–Probiotics Symbionts for Modulation of Intestinal Inflammation and Microbiome Dysregulation in Colitis Academic Background Inflammatory Bowel Disease (IBD) is a group of chronic inflammatory conditions of the gut, primarily including Crohn’s Disease (CD) and Ulcerative Colitis (UC). The pathogenesis of IBD is complex, involving dysfun...

Perceived Memory Credibility: The Role of Details

Perceived Memory Credibility: The Role of Details Academic Background In daily life, people often share personal memories to convey information, influence others, or entertain. However, distinguishing between credible and non-credible memory narratives remains a complex issue. Although forensic science has identified factors such as race, age, and ...