Functional Screen Identifies RBM42 as a Mediator of Oncogenic mRNA Translation Specificity

The occurrence and progression of cancer are closely related to the expression of oncogenes, and the regulation of oncogene expression is a complex process. Among these mechanisms, the role of translation control in oncogene expression has gradually gained attention. MYC is a key oncogene that is overexpressed in various cancers, particularly in pa...

Coupling of Cell Shape, Matrix and Tissue Dynamics Ensures Embryonic Patterning Robustness

Research Background During the early stages of mammalian embryonic development, embryonic cells gradually differentiate into various cell types through complex regulatory mechanisms, forming tissues with specific functions. This process is known as tissue patterning, which involves the determination of cell fate, coordination of cellular dynamics, ...

Spectinomycin-Loaded Antibacterial Polyvinyl Alcohol/Silver Oxide Nanobiocomposite Hydrogel: Synthesis, Characterization, Swelling, Cytotoxicity, and Controlled Drug Release Carrier

Academic Background In the field of drug delivery, achieving long-term and controlled release of drugs is a significant research direction. Hydrogels, as materials with excellent biocompatibility and degradability, have been widely used in drug delivery, tissue engineering, and wound dressing. However, the low mechanical strength of traditional hyd...

Development and Characterization of Baricitinib Nanoemulgel with Antiarthritic Effect in Rats

Academic Background Rheumatoid Arthritis (RA) is a chronic autoimmune disease that primarily affects the synovial membrane of joints, leading to inflammation and erosive lesions. Approximately 0.5% to 1% of the global population is affected by this disease, particularly among the elderly, who often experience dysphagia, which limits the compliance ...

Synthesis and Characterization of Pyrogallol Silver Nanoparticles and Pyrogallol Nanocomposites and Their Effects on Radiation-Induced Toxicity in HEK293 Cells

Academic Background Cancer is a complex and highly prevalent disease worldwide, causing nearly 10 million deaths annually. Early diagnosis and effective treatment are crucial for improving patient survival rates. Current cancer treatment modalities include surgery, chemotherapy, radiotherapy, and immunotherapy. Among these, radiotherapy is a critic...

Arabinoxylan-Incorporated Poly(ε-Caprolactone) Nanofiber Matrix Promotes Fibroblast Cell Adhesion and Proliferation

Academic Background Wound healing is a complex physiological process involving multiple coordinated stages, including hemostasis, inflammation, proliferation, and remodeling. However, in cases of severe trauma or chronic wounds, traditional treatments such as dressings and sutures often have limited efficacy. In recent years, the development of tis...