Academic Background Cardiovascular diseases, particularly atherosclerosis, are one of the leading causes of death globally. Elevated cholesterol levels are a major risk factor for atherosclerosis. Atorvastatin (ATV) is a widely used cholesterol-lowering drug, but its oral bioavailability is low, primarily due to first-pass metabolism. To improve th...

Cancer is one of the leading causes of death worldwide. Radiotherapy, as a crucial method for cancer treatment, effectively kills cancer cells but also damages normal tissues, especially sensitive tissues such as salivary glands. The oxidative stress and inflammatory reactions induced by radiotherapy are the primary causes of salivary gland dysfunc...

Kaposi’s sarcoma-associated herpesvirus (KSHV) is a γ-herpesvirus that primarily infects endothelial cells and leads to the development of Kaposi’s sarcoma (KS), especially in people living with HIV. Kaposi’s sarcoma is a malignant tumor characterized by endothelial cell proliferation, typically presenting as cutaneous lesions. After infecting endo...

Hypertrophic Cardiomyopathy (HCM) is a common inherited heart disease, affecting approximately 1 in 500 people globally. The primary characteristic of HCM is asymmetric hypertrophy of the myocardium. In its early stages, it may manifest as hyperdynamic contraction of the left ventricle (LV). However, as the disease progresses, patients may develop ...

Extracorporeal Membrane Oxygenation (ECMO) is a life-support technology used for patients with cardiac and respiratory failure. Although ECMO plays a crucial role in clinical practice, its use is accompanied by significant risks of medical device-associated thrombosis. Thrombosis not only obstructs blood flow in the oxygenator but also reduces gas ...

Skin wound healing is a complex biological process involving the coordination of cellular, molecular, and physiological events. Although traditional treatment methods can promote wound closure to some extent, their efficacy is often unsatisfactory in chronic wounds or complex trauma environments, particularly in controlling infections and inflammat...