Academic Background Cognitive control is the ability to flexibly adjust behavior according to goals and contexts, and the prefrontal cortex (PFC) plays a crucial role in this process. Previous research suggested that the PFC reads out rules from high-dimensional representations of task variables to guide behavior. However, increasing evidence indic...

Academic Background TDP-43 (TAR DNA-binding protein 43) is an RNA-binding protein primarily located in the nucleus, involved in multiple processes of RNA metabolism, including transcription, splicing, RNA transport, and translation. However, in various neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementi...

Alzheimer’s Disease (AD) is the most common form of dementia, characterized by the accumulation of amyloid-beta (Aβ) plaques and neurofibrillary tangles (NFTs) in the brain, leading to the progressive deterioration of brain function. Although Aβ plaques and NFTs have long been considered hallmarks of AD pathology, therapeutic strategies targeting t...

Neurons are the fundamental computational units of the brain, and their morphology and connectivity determine the brain’s computational capabilities. The diversity of neurons is driven by a series of waves of gene expression that guide cells through rapid developmental events, ultimately defining neuronal identity. Traditional experiments have show...

Chronic pain is a complex multidimensional experience involving sensory, emotional, and cognitive dimensions. Although traditional analgesic and antidepressant drugs are widely used, more than 50%-60% of chronic pain patients fail to benefit from them. Therefore, finding new treatment strategies has become an urgent need. In recent years, neuromodu...

Academic Background Myocardial Infarction (MI) is one of the major global health concerns. Although myeloid cells in the bone marrow (BM) are crucial for tissue repair after MI, excessive myelopoiesis can exacerbate scarring and impair cardiac function. Hematopoietic stem cells (HSCs) in the bone marrow possess unique regenerative capabilities, ena...