Decoding the Influence of Central LEAP2 on Food Intake and Its Effect on Accumbal Dopamine Release

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry,
LEAP2   Food Intake   Dopamine   Reward   Feeding   Accumbens   Liver-Expressed Antimicrobial Peptide  

Analysis of the Effect of Central LEAP-2 on Food Intake and Its Impact on Nucleus Accumbens Dopamine Release Background Introduction Gut-brain peptides such as ghrelin and their receptors have been established as important factors in regulating hunger and reward processing. However, the liver-expressed antimicrobial peptide 2 (Leap2), an inverse ag...

Control of goal-directed and inflexible actions by dorsal striatal melanocortin systems, in coordination with the central nucleus of the amygdala

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology,
dorsal striatum   melanocortin system   goal-directed behavior   inflexible actions   α-msh   caudate  

This academic paper, authored by researchers Elizabeth C. Heaton, Esther H. Seo, Laura M. Butkovich, Sophie T. Yount, and Shannon L. Gourley, primarily explores the role of the melanocortin system in the dorsal striatum in controlling goal-directed behavior and inflexible behavior, particularly in inhibiting habitual behavior in the dorsolateral st...

Genome-Wide Repeat Landscapes in Cancer and Cell-Free DNA

Genome-Wide Repeat Landscapes in Cancer and Cell-Free DNA

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Genetics,
cancer   genome-wide repeats   cell-free DNA   liquid biopsy   early detection   structural variant   epigenetics  

A Panoramic View of Whole Genome Repetitive Sequences in Cancer and Circulating Free DNA Research Background and Significance Throughout the development of cancer and other diseases, genetic changes in repetitive sequences within the genome are a significant characteristic. However, standard sequencing methods struggle to effectively characterize t...

An Electroencephalogram Microdisplay to Visualize Neuronal Activity on the Brain Surface

An Electroencephalogram Microdisplay to Visualize Neuronal Activity on the Brain Surface

Engineering, Electrical Engineering, Information Science, Electronic Information, Medicine, Anesthesiology, Neurosurgery, Life Sciences, Bioengineering,
EEG   neuronal activity   microdisplay   brain surface   microelectrocorticography   functional mapping   brain surgery  

A Visualization Microdisplay for Neuronal Activity on the Brain Surface Using Electroencephalography Background Introduction Current functional mapping in neurosurgery primarily relies on verbal communication between neurosurgeons and electrophysiologists. These processes are time-consuming and have limited resolution. Additionally, the electrode g...

Multimodal MRI Reveals Brainstem Connections That Sustain Wakefulness in Human Consciousness

Multimodal MRI Reveals Brainstem Connections That Sustain Wakefulness in Human Consciousness

Medicine, Basic Medical Sciences, Neurology, Neurosurgery, Medical Imaging,
Multimodal MRI   Brainstem   Human Consciousness   Wakefulness   Neural Network   Brain Connectivity   Neuroanatomy  

Major Breakthrough in Brain Science: Multimodal MRI Reveals Brainstem Connectivity Maintaining Human Consciousness and Wakefulness Background Introduction Consciousness comprises two fundamental components: wakefulness and awareness. Despite significant progress in understanding the cortical networks related to consciousness over the past two decad...

Electronic Health Record Signatures Identify Undiagnosed Patients with Common Variable Immunodeficiency Disease

Electronic Health Record Signatures Identify Undiagnosed Patients with Common Variable Immunodeficiency Disease

Medicine, Rheumatology and Immunology, Environmental and Public Health,
Common Variable Immunodeficiency   Electronic Health Records   Machine Learning Algorithm   Immune System   Disease Diagnosis   Artificial Intelligence   Phenotype  

Utilizing Electronic Health Record Features to Identify Undiagnosed Patients with Common Subtype of Immunodeficiency Recently, Johnson and colleagues published a study titled “Electronic health record signatures identify undiagnosed patients with common variable immunodeficiency disease” in Science Translational Medicine. This research utilizes ele...