Spatial-Aware Transformer-GRU Framework for Enhanced Glaucoma Diagnosis from 3D OCT Imaging

1. Academic Background—Innovative Diagnostic Tools Urgently Needed for Early Glaucoma Screening Glaucoma is one of the major diseases leading to irreversible blindness worldwide. According to studies such as [31], glaucoma is characterized by hidden early symptoms and irreversible visual impairment, making early detection and intervention crucial. ...

End-to-End Prediction of Knee Osteoarthritis Progression with Multimodal Transformers

End-to-end Prediction of Knee Osteoarthritis Progression Using Multimodal Transformers I. Academic Background Knee osteoarthritis (KOA) is a chronic musculoskeletal disease that affects hundreds of millions of people worldwide. Due to gradual degeneration of articular cartilage and bone, KOA typically leads to chronic pain, joint stiffness, and fun...

AI-Enhanced Lung Cancer Prediction: A Hybrid Model's Precision Triumph

Background Introduction Lung cancer, as one of the most prevalent and deadly malignant tumors worldwide, continues to pose many challenges in modern healthcare. According to literature statistics, the five-year survival rate for lung cancer patients is extremely low, consistently ranking it among the top three causes of cancer death globally. Due t...

In Silico Modeling and Validation of the Effect of Calcium-Activated Potassium Current on Ventricular Repolarization in Failing Myocytes

The Effect of Calcium-Activated Potassium Channels (SK Channels) on Repolarization in Failing Ventricular Myocytes—A Computational Modeling Study Research Background and Academic Significance Heart failure (HF) is a severe and prevalent cardiac disease, characterized by a comprehensive deterioration of the heart’s electrophysiological and contracti...

A Fresh Perspective on Deep Learning for Medical Time-Series Imputation

A New Perspective on Deep Learning for Medical Time-Series Imputation — An Interpretation of the Review “How Deep Is Your Guess? A Fresh Perspective on Deep Learning for Medical Time-Series Imputation” 1. Academic Background and Research Motivation With the ongoing development of healthcare informatization, Electronic Health Records (EHRs) have bec...

RDGuru: A Conversational Intelligent Agent for Rare Diseases

Intelligent Conversational Agent for Rare Diseases—RDGuru: Cutting-edge Technology Powers a New Revolution in Clinical Diagnosis Academic Background and Research Motivation Rare Diseases (RD) refer to disease categories that affect fewer than 6.5 to 10 individuals per 10,000 population. Their individual rarity, complex clinical features, and divers...