Targeted Nuclear Degranulation of Neutrophils Promotes the Progression of Pneumonia in Ulcerative Colitis

Medicine, Infectious Diseases, Rheumatology and Immunology, Gastroenterology, Life Sciences, Immunology,
neutrophils   targeted nuclear degranulation   ulcerative colitis   pneumonia   immune cell migration  

Academic Background Ulcerative Colitis (UC) is a chronic inflammatory bowel disease often accompanied by various extraintestinal complications, among which pulmonary infections are particularly severe. Although previous studies have indicated interactions between the intestinal and pulmonary immune systems, the specific mechanisms involving neutrop...

Computational Insights into CRISP3 Downregulation in Cervical Cancer and Its Cervical Lineages Pattern

Medicine, Obstetrics and Gynecology, Oncology,
cervical cancer   CRISP3   biomarkers   prognosis   epigenetic treatment  

Cervical Cancer (CC) is the fourth most common malignant tumor among women worldwide, particularly in low- and middle-income countries, where its incidence and mortality rates remain high. According to statistics, there were over 600,000 new cases and more than 340,000 deaths globally in 2020. The primary cause of cervical cancer is the persistent ...

Communication Between Cancer Cell Subtypes by Exosomes Contributes to Nasopharyngeal Carcinoma Metastasis and Poor Prognosis

Medicine, Oncology, Life Sciences, Cell Biology, Immunology,
cell heterogeneity   cell communication   exosomes   metastasis   nasopharyngeal carcinoma  

Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the epithelial lining of the nasopharynx, characterized by a distinct geographical distribution, particularly with high incidence rates in Southeast Asia and Southern China. Despite significant progress in NPC treatment in recent years, the prognosis for patients remains poor, esp...

Deep Learning-Based Multi-Modal Data Integration Enhancing Breast Cancer Disease-Free Survival Prediction

Information Science, Computer Science, Artificial Intelligence, Medicine, Oncology,
breast cancer   multi-modality   deep learning   pathological   disease-free survival  

Breast cancer is one of the most common malignancies among women worldwide. Although early intervention and appropriate treatment have significantly improved patient survival rates, approximately 30% of cases still experience recurrence and distant metastasis, resulting in a 5-year survival rate of less than 23%. Traditional clinical prediction met...

Suppression of Myd88 Disturbs Gut Microbiota and Activates the NLR Pathway and Hence Fails to Ameliorate DSS-Induced Colitis

Medicine, Gastroenterology, Life Sciences, Immunology,
Myd88   gut microbiota   NLR pathway   colitis   inflammatory bowel disease  

Inflammatory Bowel Disease (IBD) is a chronic, relapsing inflammatory disorder of the gastrointestinal tract, primarily including Ulcerative Colitis (UC) and Crohn’s Disease (CD). In recent years, the incidence of IBD has been on the rise globally, placing a significant burden on healthcare systems. Although it is widely accepted that IBD is associ...

Depletion of Squalene Epoxidase in Synergy with Glutathione Peroxidase 4 Inhibitor RSL3 Overcomes Oxidative Stress Resistance in Lung Squamous Cell Carcinoma

Medicine, Oncology,
lung squamous cell carcinoma   squalene epoxidase   terbinafine   reactive oxygen species   ferroptosis  

Lung cancer is one of the leading causes of death worldwide, with lung squamous cell carcinoma (LUSC) being a subtype of non-small cell lung cancer (NSCLC), accounting for 20%-30% of all NSCLC cases. Despite significant advancements in lung cancer treatment in recent years, LUSC still lacks effective targeted therapies, and patients have a poor pro...