Epstein–Barr Virus Infection Exacerbates Ulcerative Colitis by Driving Macrophage Pyroptosis via the Upregulation of Glycolysis

Academic Background Ulcerative Colitis (UC) is a chronic inflammatory bowel disease characterized by recurrent inflammation and ulceration of the colonic mucosa. Current treatments for UC primarily rely on immunosuppressive drugs, such as corticosteroids, immunomodulators, and biologics. However, the immunosuppressive properties of these drugs incr...

Predictive Model for Daily Risk Alerts in Sepsis Patients in the ICU: Visualization and Clinical Analysis of Risk Indicators

Sepsis is a systemic inflammatory response syndrome triggered by infection, often leading to multiple organ failure and high mortality rates. Although modern medical technology has made significant progress in the treatment of sepsis, some patients still die due to the rapid deterioration of their condition. Therefore, accurately predicting the mor...

The Relationship Between Contact Lens Ultraviolet Light Transmittance and Myopia Progression: A Large-Scale Retrospective Cohort Study

Research Background In recent years, the incidence of myopia has risen dramatically worldwide, particularly in East Asia, where it has become a significant public health issue. Studies suggest that nearly 50% of the global population may suffer from myopia by 2050. Myopia not only causes blurred vision but is also closely associated with various bl...

Targeting ESM1 via SOX4 Promotes the Progression of Infantile Hemangioma through the PI3K/AKT Signaling Pathway

Infantile Hemangioma (IH) is the most common benign vascular tumor in children, with an incidence rate of approximately 4%-10%. Although most IH cases resolve spontaneously, some cases may lead to permanent pigmentation, fibrous tissue accumulation, and scarring, affecting the appearance and quality of life of children. Additionally, certain IH cas...

Comparative Analysis of Tertiary Lymphoid Structures for Predicting Survival of Colorectal Cancer: A Whole-Slide Images-Based Study

Colorectal Cancer (CRC) is one of the most prevalent malignancies globally, with its prognosis closely related to immune responses within the tumor microenvironment. In recent years, Tertiary Lymphoid Structures (TLS), as an essential component of the tumor microenvironment, have been associated with favorable patient outcomes. TLS are aggregates o...

Targeted Nuclear Degranulation of Neutrophils Promotes the Progression of Pneumonia in Ulcerative Colitis

Academic Background Ulcerative Colitis (UC) is a chronic inflammatory bowel disease often accompanied by various extraintestinal complications, among which pulmonary infections are particularly severe. Although previous studies have indicated interactions between the intestinal and pulmonary immune systems, the specific mechanisms involving neutrop...