A2DM: Enhancing EEG Artifact Removal by Fusing Artifact Representation into the Time-Frequency Domain

Academic Background Electroencephalogram (EEG) is a crucial tool for studying brain activity, widely used in neuroscience, clinical diagnosis, and brain-computer interfaces. However, EEG signals are often contaminated by various artifacts during acquisition, such as electrooculography (EOG) and electromyography (EMG). These artifacts significantly ...

Odronextamab Monotherapy in Patients with Relapsed/Refractory Diffuse Large B Cell Lymphoma: Primary Efficacy and Safety Analysis in Phase 2 ELM-2 Trial

Academic Background Diffuse Large B Cell Lymphoma (DLBCL) is an aggressive form of B-cell non-Hodgkin lymphoma (B-NHL), accounting for approximately 30% of all non-Hodgkin lymphomas. Although first-line immunochemotherapy (e.g., R-CHOP regimen) has shown efficacy in DLBCL patients, about 30% of patients relapse or become refractory (relapsed/refrac...

Molecular Mechanism of the Arrestin-Biased Agonism of Neurotensin Receptor 1 by an Intracellular Allosteric Modulator

Academic Background G protein-coupled receptors (GPCRs) are the most abundant family of cell surface receptors in the human body and are also the most common targets of FDA-approved drugs. GPCRs play a crucial role in the treatment of various diseases, including pain, diabetes, cardiovascular diseases, and cancer. However, drug development targetin...

An Antibody–Toxin Conjugate Targeting CD47 Linked to the Bacterial Toxin Listeriolysin O for Cancer Immunotherapy

Academic Background Cancer immunotherapy has become a hot topic in cancer research in recent years, with its core goal being to activate the patient’s own immune system to recognize and eliminate cancer cells. However, cancer cells evade immune system attacks through various mechanisms, one of which is the expression of the “don’t eat me” signal mo...

A Force-Sensitive Adhesion GPCR is Required for Equilibrioception

Academic Background Equilibrioception is a crucial ability for mammals to perceive and navigate the three-dimensional world. This ability relies on the rapid mechanoelectrical transduction (MET) response of vestibular hair cells (VHCs), which detects the position and motion of the head. Although previous studies have shown that transmembrane channe...

Raptin, a Sleep-Induced Hypothalamic Hormone, Suppresses Appetite and Obesity

In modern society, sleep deficiency has become one of the major causes of metabolic diseases. Studies have shown that insufficient sleep increases energy intake, but its effects on energy expenditure remain unclear. Although some clinical research indicates that sleep-deprived populations exhibit greater energy intake, energy expenditure does not c...