Insulin Receptors in Vascular Smooth Muscle Cells Regulate Plaque Stability of Atherosclerosis

Medicine, Endocrinology, Cardiovascular System,
insulin receptor   smooth muscle cells   atherosclerosis   thrombospondin 1   inflammation   apoptosis   extracellular matrix  

Research Background Cardiovascular diseases (CVD) are one of the leading causes of death worldwide, particularly among patients with diabetes and insulin resistance, where the risk of CVD is significantly elevated. Although the prognosis for diabetic patients has improved in recent years, their CVD-related mortality rate remains 2 to 7 times higher...

Molecular Mechanisms of Tumor Necrosis Factor Receptor-Associated Factor 7 in Cardiac Hypertrophy

Medicine, Cardiovascular System,
cardiac hypertrophy   TRAF7   ASK1   ubiquitination   molecular mechanisms  

Academic Background Cardiac hypertrophy is a common pathophysiological process in the development of various cardiovascular diseases, such as hypertension, myocardial infarction, and congenital heart disease. Although cardiac hypertrophy is an adaptive response of the heart to adverse stimuli, long-term pathological cardiac hypertrophy can lead to ...

Fibroblast-Specific TGF-β Signaling Mediates Cardiac Dysfunction, Fibrosis, and Hypertrophy in Obese Diabetic Mice

Medicine, Endocrinology, Cardiovascular System,
Diabetic cardiomyopathy   TGF-β   Fibrosis   Heart failure   Hypertrophy  

New Mechanism of Diabetic Cardiomyopathy: The Role of Fibroblast-Specific TGF-β/Smad3 Signaling Pathway Research Background Diabetes is a significant risk factor for cardiovascular diseases and heart failure (HF) globally. Diabetic patients not only face risks of macrovascular complications such as hypertension and atherosclerosis but are also pron...

The Role of Diabetes and Age in Early Coronary Revascularization Among 'Stable' Patients with Non-ST-Segment Elevation Acute Coronary Syndromes

Medicine, Cardiovascular System,
coronary revascularization   diabetes   non-ST-segment elevation acute coronary syndrome   elderly patients   clinical outcomes  

Academic Background Non-ST-segment elevation acute coronary syndrome (NSTE-ACS) is a common cardiovascular disease, particularly among diabetic patients, whose incidence and mortality rates are significantly higher than those of non-diabetic patients. Although current clinical guidelines recommend early (within 24 hours) coronary revascularization ...

Maternal Folic Acid Over-Supplementation Impairs Cardiac Function in Mice Offspring by Inhibiting SOD1 Expression

Medicine, Obstetrics and Gynecology, Cardiovascular System, Life Sciences,
folic acid   over-supplementation   cardiac function   superoxide dismutase 1   N-acetylcysteine  

Background Folic Acid (FA) supplementation during pregnancy is widely recommended to reduce the risk of fetal congenital defects, particularly in the prevention of neural tube defects and congenital heart disease. However, despite the significant benefits of FA supplementation in preventing certain diseases, whether excessive FA supplementation may...

Interleukin-12p40 Deficiency Attenuates Myocardial Ferroptosis in Doxorubicin-Induced Chronic Cardiomyopathy by Inhibiting Th17 Differentiation and Interleukin-17A Production

Medicine, Rheumatology and Immunology, Cardiovascular System, Life Sciences, Cell Biology, Immunology,
Interleukin-12p40   Doxorubicin-induced cardiotoxicity   Ferroptosis   Inflammation   Adaptive immunity   T lymphocyte differentiation  

Academic Background Doxorubicin (Dox) is an anthracycline drug widely used in the treatment of tumors, but it exhibits dose-dependent cardiotoxicity, potentially leading to cardiomyopathy and heart failure. Despite its significant anticancer effects, the cardiotoxicity of Dox limits its clinical application. Currently, Dexrazoxane is the only FDA-a...