Acetyl-CoA Carboxylase Obstructs CD8+ T Cell Lipid Utilization in the Tumor Microenvironment

Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Acetyl-CoA Carboxylase   Tumor Microenvironment   CD8+ T Cells   Lipid Utilization   Lipid Droplets   Antitumor Immunity  

Inhibition of Acetyl-CoA Carboxylase Enhances Antitumor Immunity of Tumor-Infiltrating CD8+ T Cells Background and Objective In recent years, the impact of metabolic changes in the Tumor Microenvironment (TME) on the function of Tumor-Infiltrating Lymphocytes (TILs) has become a hot topic in immunological research. Although T cells possess strong a...

TH17 Cell-Intrinsic Glutathione/Mitochondrial-IL-22 Axis Protects Against Intestinal Inflammation

Medicine, Infectious Diseases, Rheumatology and Immunology, Gastroenterology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Th17 cells   glutathione   mitochondria   IL-22   intestinal inflammation   ROS   gut barrier  

Intrinsic Glutathione/Mitochondrial-IL-22 Axis in TH17 Cells and Its Protective Mechanism Against Intestinal Inflammation Background Introduction A large amount of reactive oxygen species (ROS) is generated in the intestine, and the role of T-cell antioxidant mechanisms in maintaining intestinal homeostasis remains unclear. This paper studies the i...

Effect of Immunosuppression in Risk of Developing Generalized Symptoms in Ocular Myasthenia Gravis

Medicine, Rheumatology and Immunology, Neurology, Ophthalmology, Life Sciences, Immunology,
immunosuppression   ocular myasthenia gravis   generalization   steroids   retrospective study  

The Effect of Immunosuppression on the Risk of Generalization in Ocular Myasthenia Gravis Background Ocular Myasthenia Gravis (OMG) is an early and localized manifestation of Myasthenia Gravis (MG), with many patients initially presenting with ocular symptoms such as fatigable ptosis and diplopia. Approximately 85% of MG patients initially exhibit ...

Efficacy of Ofatumumab and Teriflunomide in Patients with Relapsing MS from Racial/Ethnic Minority Groups: ASCLEPIOS I/II Subgroup Analyses

Medicine, Rheumatology and Immunology, Neurology,
Ofatumumab   Teriflunomide   Relapsing Multiple Sclerosis   Racial/Ethnic Minority Groups   ASCLEPIOS Trials   No Evidence of Disease Activity  

Academic Paper Report Academic Background Multiple Sclerosis (MS) is an inflammatory disease of the central nervous system characterized by the destruction of myelin and axons, leading to neurological dysfunction and progressive disability. It is estimated that there are approximately 2.8 million MS patients worldwide, with over 700,000 affected in...

Mortality and Morbidity in Adults with Rheumatic Heart Disease

Mortality and Morbidity in Adults with Rheumatic Heart Disease

Medicine, Rheumatology and Immunology, Environmental and Public Health, Cardiovascular System,
rheumatic heart disease   mortality   morbidity   valve surgery   heart failure   low- and middle-income countries  

Rheumatic Heart Disease Mortality Risk Factors Mortality and Incidence of Rheumatic Heart Disease in Adults Research Background Rheumatic heart disease (RHD) causes over 300,000 deaths annually, primarily in low- and middle-income countries (LMICs). Due to a lack of high-quality epidemiological data, understanding of the incidence and mortality of ...

Activation of Central Nervous System Immunity: A Study on Resiquimod Mechanism

Medicine, Rheumatology and Immunology, Neurology, Life Sciences, Immunology,
Resiquimod   TLR7   Central Nervous System   Immune Response   Neurocytes   Inflammatory Chemokines   NF-κB  

TLR7 Induces CCL2 Expression in Neurons via NF-κB Research Background Toll-like receptors (TLRs) are one of the important mechanisms for recognizing specific molecular structures of microbes. In humans, ten TLRs (TLR1-10) are known, among which TLR3 and TLR7 are located on the endosomal membrane and play important roles in sensing virus-derived nuc...