JAK1/2 Regulates the Synergistic Effect Between Interferon γ and Lipopolysaccharide in Microglia A research paper titled “JAK1/2 Regulates the Synergistic Effect Between Interferon γ and Lipopolysaccharide in Microglia” was published in the Journal of Neuroimmune Pharmacology in 2024. This article was completed by scholars Alexander P. Young and Ei...
Low-dose IL-2 treatment rescues cognitive deficits by repairing the imbalance between Treg and Th17 cells at the middle Alzheimer’s disease stage Background Alzheimer’s disease (AD) is an age-related neurodegenerative disorder characterized by neuronal damage, amyloid plaque deposition, and chronic inflammation in the central nervous system (CNS). ...
Association Study of Perioperative IL8 and IL18 Levels with Brain Basal Ganglia Atrophy Three Months After Surgery Background In recent years, an increasing number of studies have shown that surgical procedures may accelerate brain atrophy. Meanwhile, the relationship between systemic inflammation and neurodegenerative diseases has also received co...
TPN10475 Inhibits Effector T Lymphocyte Activation and Alleviates Experimental Autoimmune Encephalomyelitis by Promoting TGF-β Signaling Introduction Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) mediated by immune cells, with complex etiology and unclear pathogenesis. MS is characterized by ne...
Research Targeting Glucocorticoid Receptor-CCR8 Axis Mediated Bone Marrow T Cell Sequestration to Enhance Anti-tumor T Cell Infiltration in Intracranial Cancer Background Brain tumors, especially glioblastomas (GBMs), show significant resistance to immune checkpoint blockade therapy, partly due to limited T cell infiltration into tumors. GBMs accou...
Background Introduction Sterile neuroinflammation is an important factor driving various neurological diseases. Myelin debris, released during the demyelination process in various neurological diseases (such as stroke, spinal cord injury (SCI), multiple sclerosis (MS), traumatic brain injury (TBI), and neurodegenerative diseases), can act as an inf...