Microglia and Macrophages in Glioblastoma: Landscapes and Treatment Directions

Medicine, Neurology, Neurosurgery, Oncology, Life Sciences, Immunology,
glioblastoma   microglia   macrophages   tumor microenvironment   immunotherapy   single-cell sequencing   tumor-associated macrophages  

Microglia and Macrophages in Glioblastoma Academic Background Glioblastoma (GBM) is the most common primary malignant tumor of the central nervous system, characterized by high invasiveness and lethality. Despite standard treatments such as surgery, chemotherapy, and radiotherapy, the survival rate of patients remains extremely limited, with a medi...

From Bedside to Bench: New Insights in Epilepsy-Associated Tumors Based on Recent Classification Updates and Animal Models on Brain Tumor Networks

Medicine, Neurology, Neurosurgery, Medical Imaging, Oncology,
low-grade neuroepithelial tumors   epilepsy   in utero electroporation   mouse model   neuronal activity   brain tumors   neuro-oncology  

Latest Research on Epilepsy-Associated Tumors: Classification and Animal Models Background Epilepsy is a common neurological disorder, and some patients are accompanied by brain tumors, particularly low-grade neuroepithelial tumors (LGNTs). These tumors typically grow slowly but are highly associated with drug-resistant epilepsy. Although research ...

The Multifaceted Therapeutical Role of Low-Density Lipoprotein Receptor Family in High-Grade Glioma

Medicine, Neurology, Neurosurgery, Oncology,
Low-Density Lipoprotein Receptor   High-Grade Glioma   Targeted Therapies   Tumorigenesis   Signaling Pathways  

The Multifaceted Therapeutic Role of the Low-Density Lipoprotein Receptor Family in High-Grade Glioma Academic Background High-grade gliomas (HGG) are the most aggressive and prevalent primary brain tumors in the central nervous system (CNS), accounting for approximately 80% of all malignant brain tumors. Among them, glioblastoma (GBM) is the most ...

Breaking Boundaries: Role of the Brain Barriers in Metastatic Process

Medicine, Neurology, Oncology,
brain metastasis   blood-brain barrier   blood-spinal cord barrier   blood-cerebrospinal fluid barrier   cancer   metastatic mechanisms   therapeutic challenges  

The Role of Brain Barriers in Brain Metastasis Background Introduction Brain metastases (BMs) are the most common intracranial tumors in adults, occurring 3 to 10 times more frequently than primary brain tumors. Despite multimodal treatments including surgical resection, radiotherapy, and chemotherapy, the prognosis for brain metastases remains poo...

The Influence of Glioblastoma Differentiation on Blood-Brain Barrier Permeability

Medicine, Neurology, Oncology,
Glioblastoma   Blood-Brain Barrier   Permeability   IL-6   STAT3   Tumor Differentiation   Drug Delivery  

The Impact of Glioblastoma Differentiation on Blood-Brain Barrier Permeability Background Introduction Glioblastoma Multiforme (GBM) is a highly aggressive brain tumor, and its treatment is extremely challenging due to its complex biological characteristics and the presence of the Blood-Brain Barrier (BBB). The BBB is a complex structure composed o...

Signal Integrator Function of CXXC5 in Cancer

Medicine, Oncology, Life Sciences, Cell Biology, Immunology, Genetics,
CXXC5   cell signaling   cancer   targeting therapy   epigenetic regulation   Wnt/β-catenin pathway   TGF-β/BMP pathway  

Signal Integrator Function of CXXC5 in Cancer Academic Background CXXC5 (CXXC-type zinc finger protein 5) is a member of the ZF-CXXC protein family and plays a pivotal role in signal integration and information transfer within the cellular signaling network. By regulating multiple signaling pathways (such as Wnt/β-catenin, TGF-β/BMP, ATM/p53, etc.)...