Research Report on the Academic Paper Title: Advanced Single-Cell and Spatial Analysis with High-Multiplex Characterization of Circulating Tumor Cells and Tumor Tissue in Prostate Cancer: Unveiling Resistance Mechanisms with the CODuco In Situ Assay Authors: Lilli Bonstingl et al. Journal: Biomarker Research (2024) 12:140 DOI: 10.1186/s40364-024-00...

Research Objective This study aims to identify specific proteins secreted by prostate cancer cells through comprehensive proteomic analysis and explore their role in bone metastasis, with the goal of discovering blood biomarkers that can improve the prognosis of patients with metastatic castration-resistant prostate cancer (mCRPC). Research Team an...

FBXL16: A New Regulator of Neuroinflammation and Cognition in Alzheimer’s Disease through Ubiquitination-Dependent Degradation of Amyloid Precursor Protein Academic Background Alzheimer’s Disease (AD) is an age-related neurodegenerative disorder characterized by progressive cognitive decline. With the global aging population, the incidence of neuro...

Global Surveillance of Circulating MicroRNA for Diagnostic and Prognostic Assessment of Acute Myocardial Infarction Based on Plasma Small RNA Sequencing Academic Background Acute Myocardial Infarction (AMI) is one of the most severe cardiovascular diseases leading to human mortality and morbidity worldwide. The pathological mechanism of AMI primari...

Acute myeloid leukemia (AML) is the most common type of leukemia in adults. Although most AML patients achieve complete remission after standard chemotherapy, refractory and relapsed disease remain a significant challenge. Over the past decade, immunotherapy has been widely applied in cancer treatment, particularly chimeric antigen receptor T-cell ...

Report on the Academic Paper Inflammatory skin diseases, such as psoriasis and rosacea, are common chronic skin conditions worldwide, significantly impacting patients’ quality of life. Traditional topical drug delivery methods, while simple and non-invasive, suffer from poor skin penetration and long-term side effects. Therefore, developing an effe...

Exosomal PSM-E Inhibits Macrophage M2 Polarization to Suppress Prostate Cancer Metastasis via the RACK1 Signaling Axis Academic Background Prostate cancer (PCA) is a prevalent cancer among men and the second leading cause of cancer-related deaths. While early-stage prostate cancer can be treated with surgery or radiotherapy, approximately one-third...

Single-Cell Analysis Reveals Differences Between Aged and Young Mouse Prostates Academic Background The prostate is a vital component of the male reproductive system. As men age, the prostate undergoes hyperplasia, which can lead to urethral compression, resulting in voiding dysfunction and associated symptoms, as well as an increased risk of prost...

Study on a Prognostic Blood-Based Sphingolipid Panel for Men with Localized Prostate Cancer on Active Surveillance Academic Background Prostate cancer is one of the most common cancers among men globally, particularly for those with low- and intermediate-risk prostate cancer, where active surveillance (AS) has become the preferred management strate...

The Spatial Impact of a Western Diet in Enriching Galectin-1-Regulated Rho, ECM, and SASP Signaling in a Novel MASH-HCC Mouse Model Academic Background Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, and metabolic dysfunction-associated steatohepatitis (MASH) is one of the primary triggers of HCC. With ...