Research Priorities for Improving Cognitive and Neuropsychological Outcomes in Hydrocephalus

Medicine, Psychiatry, Neurology, Neurosurgery, Clinical Psychology,
hydrocephalus   neuropsychology   cognition   research priorities   quality of life   clinical assessment   animal models  

Research Priorities for Improving Cognitive and Neuropsychological Outcomes in Hydrocephalus Academic Background Hydrocephalus is a neurological disorder affecting approximately 85 per 100,000 individuals worldwide. It is closely associated with motor and cognitive impairments. Although advancements in surgical interventions have significantly impr...

The Utility of Customised Tissue Probability Maps and Templates for Patients with Idiopathic Normal Pressure Hydrocephalus: A Computational Anatomy Toolbox (CAT12) Study

Medicine, Neurology, Medical Imaging,
brain tissue segmentation   CAT12   idiopathic normal pressure hydrocephalus   spatial normalisation   template  

Improving the Accuracy of Brain Image Analysis in Patients with Idiopathic Normal Pressure Hydrocephalus Using Customized Tissue Probability Maps and Templates Academic Background Idiopathic Normal Pressure Hydrocephalus (iNPH) is a common neurological disorder characterized by gait disturbance, cognitive decline, and urinary incontinence. One of t...

A Novel Method to Study CSF Flow and BOLD Coupling Using Real-Time Phase Contrast Interleaved with Cortical BOLD MRI

Medicine, Neurology, Medical Imaging, Life Sciences, Biophysics,
CSF flow   real-time phase contrast   BOLD   glymphatic system   brain clearance   BOLD-CSF coupling  

New Method for Studying the Coupling Between Cerebrospinal Fluid Flow and Cortical BOLD Signals Academic Background In recent years, the role of cerebrospinal fluid (CSF) in brain waste clearance has garnered significant attention. Traditionally, CSF was thought to primarily serve as a cushion and provide immune surveillance. However, growing evide...

Choroid Plexus Aging: Structural and Vascular Insights from the HCP-Aging Dataset

Medicine, Geriatrics, Neurology, Medical Imaging,
choroid plexus   aging   human connectome project   perfusion function   vascular degeneration  

Research on Choroid Plexus Aging and Cerebrospinal Fluid Dynamics Background Introduction The choroid plexus (CHP) is a highly vascularized structure located within the brain ventricles, primarily responsible for the production of cerebrospinal fluid (CSF) and the clearance of metabolic waste. It plays a crucial role in maintaining neurofluid homeo...

Lumped Parameter Simulations of Cervical Lymphatic Vessels: Dynamics of Murine Cerebrospinal Fluid Efflux from the Skull

Physics, Fluid Physics, Engineering, Mechanical Engineering, Medicine, Neurology,
cervical lymphatic vessels   lymphatic system   cerebrospinal fluid   traumatic brain injury   numerical simulation   fluid dynamics   intracranial pressure  

Numerical Simulation Study of Cerebrospinal Fluid Drainage through Cervical Lymphatic Vessels Background Introduction Cerebrospinal fluid (CSF) is a clear fluid that circulates around the brain and spinal cord, providing physical protection, nutrient supply, and waste clearance for the central nervous system. In recent years, growing evidence sugge...

Development and Application of an Automated In Vitro Model for Hydrocephalus Research

Medicine, Neurology, Life Sciences, Bioengineering,
hydrocephalus   in vitro modeling   cerebrospinal fluid flow pattern   CSF dynamics   microfluidic   pump   bioreactor  

Application of Automated In Vitro Models in Hydrocephalus Research Background Introduction Hydrocephalus is a neurological condition caused by the accumulation of cerebrospinal fluid (CSF) in the brain’s ventricles. If left untreated, it can lead to severe complications and permanent brain damage. It is estimated that 1 in every 500 newborns is bor...