Organ-Specific Microenvironments Drive Divergent T Cell Evolution in Acute Graft-Versus-Host Disease

Medicine, Rheumatology and Immunology, Hepatobiliary System, Respiratory System, Gastroenterology, Hematology, Life Sciences, Immunology,
Graft-versus-host disease   T cell evolution   Organ microenvironment   Immunopathology   Single-cell RNA sequencing  

Study on Organ-Specific T Cell Differentiation in Acute Graft-Versus-Host Disease (AGVHD) Academic Background Acute Graft-Versus-Host Disease (AGVHD) is a common and severe complication following Allogeneic Hematopoietic Stem Cell Transplantation (HCT), caused by the immune attack of donor T cells on host tissues. Although the pathological mechanis...

Triple Knockdown of CD11a, CD49d, and PSGL1 in T Cells Reduces CAR-T Cell Toxicity but Preserves Activity Against Solid Tumors in Mice

Medicine, Oncology, Life Sciences, Cell Biology, Immunology,
CAR-T cells   solid tumors   immunotherapy   cell adhesion   cell migration  

Study on Reducing Toxicity of CAR-T Cell Therapy for Solid Tumors Academic Background Chimeric antigen receptor T-cell (CAR-T) therapy has made significant progress in treating hematologic malignancies, but its application in solid tumors faces major challenges. Solid tumors often lack tumor-specific antigens (TSAs), and CAR-T cells may attack norm...

Ciliopathies: Undocking of an Extensive Ciliary Network Induces Proteostasis and Cell Fate Switching Resulting in Severe Primary Ciliary Dyskinesia

Medicine, Respiratory System, Life Sciences, Cell Biology, Biochemistry, Genetics,
Primary Ciliary Dyskinesia   Ciliary Network   Proteostasis   Cell Fate Switching   Gene Therapy  

Research on Ciliary Diseases: The Role of CCDC39/CCDC40 Heterodimer in Primary Ciliary Dyskinesia Academic Background Primary Ciliary Dyskinesia (PCD) is a rare monogenic disorder characterized by chronic respiratory infections, infertility, and organ laterality defects. Although more than 50 genes associated with PCD have been identified, mutation...

Early-Onset Sleep Alterations Found in Patients with Amyotrophic Lateral Sclerosis Are Ameliorated by Orexin Antagonist in Mouse Models

Medicine, Neurology,
Amyotrophic Lateral Sclerosis   Sleep Alterations   Orexin Antagonist   Mouse Models   Neurodegenerative Diseases   Cognitive Function   Hypothalamic Signaling  

Mechanisms and Therapeutic Exploration of Early Sleep Abnormalities in Patients with Amyotrophic Lateral Sclerosis Academic Background Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by the degeneration of motor neurons, leading to progressive muscle weakness and respiratory failure. Although the primary symptoms ...

Selective Abrogation of S6K2 Identifies Lipid Homeostasis as a Survival Vulnerability in MAPK Inhibitor–Resistant NRAS-Mutant Melanoma

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
NRAS-mutant melanoma   MAPK inhibitor resistance   lipid metabolism   S6K2   PPARα  

Academic Background NRAS-mutant (NRASmut) melanoma is a highly aggressive tumor type, accounting for nearly 30% of all melanoma cases. NRAS is an oncogene that persistently activates the mitogen-activated protein kinase (MAPK) signaling pathway, which plays a critical role in melanoma development. However, despite extensive research on MAPK pathway...

Pseudomonas aeruginosa Infection Induces Lung Transplant Antibody-Mediated Rejection

Medicine, Infectious Diseases, Life Sciences, Immunology,
Pseudomonas aeruginosa   lung transplantation   antibody-mediated rejection   lymphocytotoxicity   bacterial infection  

Pseudomonas aeruginosa Infection Induces Antibody-Mediated Rejection in Lung Transplantation Academic Background Introduction Lung transplantation is a critical treatment for end-stage lung diseases, but post-transplant rejection remains a major challenge affecting long-term patient survival. Antibody-mediated rejection (AMR) is an increasingly rec...