Fixational Eye Movements as Active Sensation for High Visual Acuity

Medicine, Neurology, Ophthalmology, Life Sciences, Biophysics,
fixational eye movements   visual acuity   retinal coding   Bayesian inference   adaptive optics  

Fixational Eye Movements as Active Sensation for High Visual Acuity Academic Background Human visual perception is a complex process, especially when we attempt to maintain stable gaze. Even then, the eyes still produce small involuntary movements known as fixational eye movements (FEM). These FEM typically include drifts and microsaccades. Previou...

Intracranial Substrates of Meditation-Induced Neuromodulation in the Amygdala and Hippocampus

Medicine, Neurology, Life Sciences,
meditation   amygdala   hippocampus   neuromodulation   electrophysiology  

Study on the Neuroregulatory Effects of Meditation: A Case Study of Loving-Kindness Meditation Academic Background Meditation, as a mental training technique, has long been believed to regulate emotions and enhance mental health. Specifically, Loving-Kindness Meditation (LKM), which focuses on cultivating positive emotions towards oneself and other...

Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups

Medicine, Urology, Oncology, Life Sciences, Genetics,
Genome-wide association study   Prostate-specific antigen   Multiancestry groups   Genetic prediction   Prostate cancer screening  

Multi-Ancestry Genome-Wide Association Study Reveals New Loci for Prostate-Specific Antigen Levels and Improves Prediction Across Ancestral Groups Research Background and Problem Statement Prostate-specific antigen (PSA) is a protein secreted by the prostate gland, commonly used for prostate cancer screening. However, PSA levels are influenced not ...

Mechanistic Insights into Inactivating Mutations in the Proton-Coupled Folate Transporter (SLC46A1), and Compensatory Mutations that Restore Function

Chemistry, Physical Chemistry, Medicinal Chemistry, Computational Chemistry, Medicine, Life Sciences, Biochemistry, Genetics,
Proton-Coupled Folate Transporter   Inactivating Mutations   Functional Restoration   Molecular Dynamics Simulation   Hereditary Folate Malabsorption  

Research Background and Problem Statement Hereditary Folate Malabsorption (HFM) is a rare autosomal recessive disorder characterized by impaired intestinal absorption of folates and hindered transport across the choroid plexus into cerebrospinal fluid. This disease is caused by inactivating mutations in the gene encoding the Proton-Coupled Folate T...

A Statistical Framework for Multi-Trait Rare Variant Analysis in Large-Scale Whole-Genome Sequencing Studies

Medicine, Life Sciences, Biochemistry, Bioengineering, Genetics,
statistical framework   rare variants   multi-trait analysis   whole-genome sequencing   functional annotations  

A New Framework for Multi-Trait Rare Variant Analysis: Multistaar Research Background and Problem Statement With the advancement of next-generation sequencing technologies and the decreasing cost of whole-genome sequencing (WGS), researchers can delve deeper into the impact of rare variants on complex human traits. However, single-trait analysis me...

The Association of Physical Activity Fragmentation with All-Cause Mortality in Hispanics: A Prospective Cohort Study

Medicine, Environmental and Public Health, Sports Medicine,
physical activity   fragmentation   sedentary   mortality   Hispanics   Latinos  

Research Background and Question In modern society, the patterns of physical activity (PA) and their impact on health have been a critical area of public health and medical research. Traditional studies have primarily focused on the total volume and intensity of physical activity. However, in recent years, an increasing number of studies have begun...