Pseudomonas aeruginosa Infection Induces Antibody-Mediated Rejection in Lung Transplantation Academic Background Introduction Lung transplantation is a critical treatment for end-stage lung diseases, but post-transplant rejection remains a major challenge affecting long-term patient survival. Antibody-mediated rejection (AMR) is an increasingly rec...

Academic Background and Problem Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive cancer with an extremely low five-year survival rate, primarily due to late diagnosis and limited treatment options. Approximately 95% of PDAC patients harbor KRAS mutations, with the KRAS-G12D mutation being the most common. Although KRAS mutations have long b...

Study on Congenital Immune Dysfunction in Cystic Fibrosis Research Background Cystic Fibrosis (CF) is a genetic disease caused by mutations in the CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) gene, primarily affecting the lungs and digestive system. One of the major problems faced by CF patients is recurrent infections and inflammatio...

Impact of Omega-3 Fatty Acids on Lipidomics and Gut Microbiome in Patients with Type 2 Diabetes Background Type 2 Diabetes (T2D) is a common metabolic disorder worldwide, often accompanied by lipid abnormalities such as hypertriglyceridemia (HTG). Lipid abnormalities are significant risk factors for cardiovascular disease (CVD), especially high tri...

GNAO1 (G protein alpha subunit O1) gene mutations are considered one of the primary causes of severe pediatric encephalopathy. This encephalopathy typically manifests as epilepsy, movement disorders, developmental delay, and intellectual disability, with limited effectiveness of current treatments. The GαO protein encoded by the GNAO1 gene is a key...

G-Quadruplexes Catalyze Protein Folding: A Research Report Academic Background Protein folding is a complex and unsolved problem in biology. Many proteins fold very slowly in vitro, far exceeding the time ranges acceptable under physiological conditions. To address this challenge, ATP (adenosine triphosphate)-dependent chaperonins are thought to ac...